Penile Rehabilitation After Prostate Cancer Treatment: Outcomes and Practical Algorithm

被引:18
作者
Mazzola, Clarisse [1 ]
Mulhall, John P. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Male Sexual & Reprod Med Program, Div Urol, New York, NY 10065 USA
关键词
Penile rehabilitation; Radical prostatectomy; Erectile dysfunction; Prostate cancer; RADICAL RETROPUBIC PROSTATECTOMY; ACCESSORY PUDENDAL ARTERIES; CAVERNOUS NERVE INJURY; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL PROGENITOR CELLS; ERECTILE FUNCTION RECOVERY; ON-DEMAND VARDENAFIL; K-ATP CHANNELS; SILDENAFIL CITRATE; SMOOTH-MUSCLE;
D O I
10.1016/j.ucl.2011.03.002
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The number of patients diagnosed with prostate cancer was estimated to be 192,000 in 2009 according to the American Cancer Society. The prevalence of reported erectile dysfunction after radical prostatectomy has significant variance. Among the studies in which the nerve-sparing status was described, erectile function recovery adequate for sexual intercourse was achieved in 50% of patients. This article reviews the animal and human studies in this field and provides a useful penile rehabilitation algorithm.
引用
收藏
页码:105 / +
页数:15
相关论文
共 93 条
[1]   Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells [J].
Aicher, A ;
Heeschen, C ;
Mildner-Rihm, C ;
Urbich, C ;
Ihling, C ;
Technau-Ihling, K ;
Zeiher, AM ;
Dimmeler, S .
NATURE MEDICINE, 2003, 9 (11) :1370-1376
[2]   Recovery of erectile function after nerve-sparing radical prostatectomy:: improvement with nightly low-dose sildenafil [J].
Bannowsky, Andreas ;
Schulze, Heiko ;
van der Horst, Christof ;
Hautmann, Stefan ;
Juenemann, Kalus-Peter .
BJU INTERNATIONAL, 2008, 101 (10) :1279-1283
[3]   Expression of Caveolin-1 in Penile Cavernosal Tissue in a Denervated Animal Model after Treatment with Sildenafil Citrate [J].
Becher, Edgardo F. ;
Toblli, Jorge E. ;
Castronuovo, Cynthia ;
Nolazco, Carlos ;
Rosenfeld, Claudio ;
Grosman, Halina ;
Vazquez, Elba ;
Mazza, Osvaldo N. .
JOURNAL OF SEXUAL MEDICINE, 2009, 6 (06) :1587-1593
[4]   Chronic sildenafil improves erectile function and endothelium-dependent cavernosal relaxations in rats:: Lack of tachyphylaxis [J].
Behr-Roussel, D ;
Gorny, D ;
Mevel, K ;
Caisey, S ;
Bernabé, J ;
Burgess, G ;
Wayman, C ;
Alexandre, L ;
Giuliano, F .
EUROPEAN UROLOGY, 2005, 47 (01) :87-91
[5]   Supra and infralevator neurovascular pathways to the penile corpora cavernosa [J].
Benoit, G ;
Droupy, S ;
Quillard, J ;
Paradis, V ;
Giuliano, F .
JOURNAL OF ANATOMY, 1999, 195 :605-615
[6]   Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis [J].
Bivalacqua, Trinity J. ;
Liu, Tongyun ;
Musicki, Bijana ;
Champion, Hunter C. ;
Burnett, Arthur L. .
EUROPEAN UROLOGY, 2007, 51 (06) :1732-1740
[7]   OBJECTIVE MEASUREMENT OF THE EFFECTIVENESS, THERAPEUTIC SUCCESS AND DYNAMIC MECHANISMS OF THE VACUUM DEVICE [J].
BOSSHARDT, RJ ;
FARWERK, R ;
SIKORA, R ;
SOHN, M ;
JAKSE, G .
BRITISH JOURNAL OF UROLOGY, 1995, 75 (06) :786-791
[8]   Sacrifice of Accessory Pudendal Arteries in Normally Potent Men during Robot-Assisted Radical Prostatectomy Does Not Impact Potency [J].
Box, Geoffrey N. ;
Kaplan, Adam G. ;
Rodriguez, Esequiel, Jr. ;
Skarecky, Douglas W. ;
Osann, Kathryn E. ;
Finley, David S. ;
Ahlering, Thomas E. .
JOURNAL OF SEXUAL MEDICINE, 2010, 7 (01) :298-303
[9]   DETAILED ANATOMY OF PENILE NEUROVASCULAR STRUCTURES - SURGICAL SIGNIFICANCE [J].
BREZA, J ;
ABOSEIF, SR ;
ORVIS, BR ;
LUE, TF ;
TANAGHO, EA .
JOURNAL OF UROLOGY, 1989, 141 (02) :437-443
[10]   Cavernous nerve injury using rodent animal models [J].
Canguven, Onder ;
Burnett, Arthur .
JOURNAL OF SEXUAL MEDICINE, 2008, 5 (08) :1776-1785