Viral IAPs, then and now

被引:48
作者
Clem, Rollie J. [1 ]
机构
[1] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA
关键词
Apoptosis; IAP; Baculovirus; Insect virus; APOPTOSIS INHIBITORY PROTEIN; NUCLEAR POLYHEDROSIS-VIRUS; FUNCTIONAL-ANALYSIS; BACULOVIRUS INHIBITOR; DROSOPHILA INHIBITOR; NUCLEOPOLYHEDROVIRUS IAP2; CELL-DEATH; OP-IAP; GENE; CASPASE;
D O I
10.1016/j.semcdb.2015.01.011
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The identification, now more than 20 years ago, of the first iap genes in baculoviruses subsequently led to many important discoveries concerning the regulation of apoptosis and other important biological processes in insects and mammals. Currently there are more than 200 known viral IAP homologs in baculoviruses and other families of invertebrate DNA viruses. This review begins with a personal account of the events leading up to the discovery of the first iap genes, followed by a summary of what is currently known about the different types of viral IAPs and their functions in regulating apoptosis, and possibly other cellular processes. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:72 / 79
页数:8
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