Dietary natural products and lung cancer: Effects and mechanisms of action

被引：40
作者：
Cao, Shi-Yu [1 ]
Li, Ya [1 ]
Meng, Xiao [1 ]
Zhao, Cai-Ning [1 ]
Li, Sha [2 ]
Gan, Ren-You [3 ]
Li, Hua-Bin [1 ,4 ]
机构：
[1] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China
[2] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China
[4] Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Guangdong, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2019年 / 52卷
基金：
中国国家自然科学基金;
关键词：
Lung cancer; Fruit; Vegetable; Spice; Anticancer; Mechanism; A549 HUMAN LUNG; GRAPE SEED PROANTHOCYANIDINS; CELL-PROLIFERATION; IN-VITRO; POMEGRANATE FRUIT; INHIBITS GROWTH; ANTIPROLIFERATIVE ACTIVITY; ANTIOXIDANT CAPACITIES; MOMORDICA-CHARANTIA; ANTHOCYANIN CONTENT;
D O I：
10.1016/j.jff.2018.11.004
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Lung cancer is the most common cancer and the leading cause of cancer-related death worldwide. Increasing evidence suggests an important role of dietary natural products in the prevention and management of lung cancer, such as grapes, pomegranates, apples, cruciferous vegetables, tomatoes, bitter melons, turmeric, ginger, saffron, garlic, chili, rosemary, soy, rice bran, corn, shiitake mushroom, Calvatia gigantea, and Thelephora ganbajun. These edible natural products and their bioactive constituents influence cancer development and progression through multiple ways, including suppressing cancer cell growth and proliferation, inducing cell apoptosis, protecting against lung carcinogens, inhibiting cell migration and adhesion, and immunomodulating and sensitizing cancer cells to antitumor drugs. This review focuses on the potential prevention and management of lung cancer using dietary natural products and their relevant bioactive components, and discusses the possible mechanisms of action.
引用
收藏
页码：316 / 331
页数：16
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