INVESTIGATING THE OPTIMAL INITIATION TIME OF ULTRASOUND THERAPY FOR PERIPHERAL NERVE REGENERATION AFTER AXONOTMESIS IN RATS

被引：7

作者：

Kawai, Hideki ^{[1
,2
]}

Ito, Akira ^{[1
]}

Wang, Tianshu ^{[3
]}

Xu, Shixuan ^{[1
]}

Kuroki, Hiroshi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Motor Funct Anal, Human Hlth Sci, Kyoto, Japan

[2] Japan Soc Promot Sci, Tokyo, Japan

[3] Kyoto Univ, Dept Dev & Rehabil Motor Funct, Human Hlth Sci, Grad Sch Med, Kyoto, Japan

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2022年 / 48卷 / 02期

关键词：

Ultrasound therapy; Peripheral nerve injury; Functional recovery; Nerve regeneration; Time factors; INTENSITY PULSED ULTRASOUND; AXONAL REGENERATION; ELECTRICAL-STIMULATION; SCHWANN-CELLS; WALLERIAN DEGENERATION; NEUROTROPHIC FACTOR; CRUSH INJURY; PROLIFERATION; MACROPHAGES; EXPRESSION;

D O I：

10.1016/j.ultrasmedbio.2021.09.023

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

This study was aimed at identifying the optimal initiation time of ultrasound (US) therapy for peripheral nerve regeneration after axonotmesis. Thirty-six rats with sciatic nerve crush injury were divided into four groups that received US irradiation initiated 1, 7 or 14 d after injury, or sham stimulation for 4 wk. Motor function analysis was conducted weekly; however, there was no significant improvement attributed to US treatment. Four weeks after injury, compound muscle action potential amplitude values of the group in which US irradiation was initiated 1 d after the injury exhibited significant improvement compared with the sham stimulation group. In addition, myelin sheath thick-ness was significantly greater in the 1-d group than in other groups. These results indicate that US treatment initiated 1 d after peripheral nerve injury promotes maximum regeneration. (C) 2021 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

引用

页码：304 / 312

页数：9

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