Quantitative trait loci implicated in corpus callosum midsagittal area in mice

被引：6

作者：

Le Roy, I ^{[1
]}

Perez-Diaz, F ^{[1
]}

Roubertoux, P ^{[1
]}

机构：

[1] UPR CNRS 9074, Inst Transgenose, F-45071 Orleans 02, France

来源：

BRAIN RESEARCH | 1998年 / 811卷 / 1-2期

关键词：

corpus callosum; mouse; gene mapping; CCrSQTL(1); CCrSQTL(2);

D O I：

10.1016/S0006-8993(98)00975-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The midsagittal area of the corpus callosum expressed as the percentage of the hemispheric surface is smaller in the NZB/BINJ than in the C57BL/6By inbred strain of mice. We performed a QTL mapping analysis using 284 F(2)s. Two loci linked to this measure were found: the CCrSQTL(1) and CCrSeTL2 at 87 and 67 centiMorgans from the centromere on chromosomes 1 and 4 respectively. The two loci interacted significantly. The total source of genetic variation contributed to 25% of the observed variance; (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：173 / 176

页数：4

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