Deciphering the TCR Repertoire to Solve the COVID-19 Mystery

被引：47

作者：

Gutierrez, Lucas ^{[1
]}

Beckford, John ^{[1
]}

Alachkar, Houda ^{[1
]}

机构：

[1] Univ Southern Calif, Sch Pharm, Dept Clin Pharm, Los Angeles, CA 90089 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2020年 / 41卷 / 08期

关键词：

T-CELL RESPONSE; IMMUNE-RESPONSE; CLASS-I; SELECTION; RECOGNITION; INFECTION; REGION; GENES; BLOOD;

D O I：

10.1016/j.tips.2020.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date. Im- portant questions have remained unanswered: why some patients develop se- vere disease, while others do not; and what roles do genetic variabilities play in the individual immune response to this viral infection. Here, we discuss the crit- ical role T cells play in the orchestration of the antiviral response underlying the pathogenesis of the disease, COVID-19. We highlight the scientific rationale for comprehensive and longitudinal TCR analyses in COVID-19 and reason that an- alyzing TCR repertoire in COVID-19 patients would reveal important findings that may explain the outcome disparity observed in these patients. Finally, we pro- vide a framework describing the different strategies, the advantages, and the challenges involved in obtaining useful TCR repertoire data to advance our fight against COVID-19.

引用

页码：518 / 530

页数：13

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