Combining Magnetic Resonance Imaging with Photothermal Therapy of CuS@BSA Nanoparticles for Cancer Theranostics

被引：34

作者：

Chu, Zhongyun ^{[1
]}

Wang, Zhiming ^{[1
]}

Chen, Lina ^{[3
]}

Wang, Xiaoshuang ^{[3
]}

Huang, Chusen ^{[1
]}

Cui, Malin ^{[2
]}

Yang, Da-Peng ^{[2
]}

Jia, Nengqin ^{[1
]}

机构：

[1] Shanghai Normal Univ, Dept Chem, Shanghai Key Lab Rare Earth Funct Mat, Educ Minist,Key Lab Resource Chem, Shanghai 200234, Peoples R China

[2] Quanzhou Normal Univ, Coll Chem Engn & Mat Sci, Quanzhou 362000, Peoples R China

[3] Yangtze Univ, Clin Med Coll 2, Jingzhou Cent Hosp, Jingzhou 434020, Peoples R China

来源：

ACS APPLIED NANO MATERIALS | 2018年 / 1卷 / 05期

基金：

中国国家自然科学基金;

关键词：

CuS@BSA nanoparticles; theranostics; low cytotoxicity; photothermal therapy (PTT); MRI contrast agent; COPPER SULFIDE NANOPARTICLES; DRUG-DELIVERY SYSTEM; POLYPYRROLE NANOPARTICLES; AGENT; ABLATION; OXIDE; NANOCOMPOSITES; NANOSHEETS; NANORODS; NANOCRYSTALS;

D O I：

10.1021/acsanm.8b00410

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The treatment of tumors has been a wide concern by a large number of scientific researchers. Combining magnetic resonance imaging (MRI) with photothermal therapy (PTT) enables cancer theranostics to be more efficient and accurate. Herein, we synthesized CuS@BSA nanoparticles with an average grain diameter of about 16.5 nm through a facile one-pot eco-friendly and user-friendly strategy and it was found to have strong near-infrared absorption property and magnetic resonance imaging ability so that it can be utilized as a multifunctional agent for cancer theranostic. The in vitro toxicity study showed that CuS@BSA nanoparticles with low toxicity could kill cancer cells with the 980 nm NIR laser effectively. Furthermore, they exhibit a certain value of relaxivity (r(1) = 0.26 mM(-1).s(-1)) compared to that of clinically widely used reagent Magnevist (r(1) = 3.13 mM(-1).s(-1)). The resulting product of CuS@BSA nanoparticles with their magnetic resonance imaging (MRI) and photothermal therapeutic capabilities could represent a kind of potential candidate for cancer theranostics.

引用

页码：2332 / 2340

页数：17

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