The role of neurogenesis during development and in the adult brain

被引：22
|
作者：
Jin, Xing [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Suzhou Municipal Hosp, Dept Pharm, Suzhou 215001, Peoples R China
来源：
EUROPEAN JOURNAL OF NEUROSCIENCE | 2016年 / 44卷 / 06期
关键词：
development; embryonic and adult neurogenesis; neural stem cells; neuropsychiatric disease; NEWLY GENERATED NEURONS; HIPPOCAMPAL NEUROGENESIS; OLFACTORY-BULB; SUBVENTRICULAR ZONE; ALZHEIMERS-DISEASE; NMDA RECEPTORS; BORN NEURONS; LEARNING INCREASES; DENTATE GYRUS; PROGENITOR CELLS;
D O I：
10.1111/ejn.13251
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neural stem cells (NSCs) give rise to neurons during development. NSCs persist and neurogenesis continues in restricted regions of postnatal and adult brains. Adult-born neurons integrate into existing neural circuits by synaptic connections and participate in the regulation of brain function. Thus, understanding NSCs and neurogenesis may be crucial in the development of new strategies for brain repair. Here, we introduce the lineage of NSCs from embryonic to adult stages and summarize recent studies on maturation and integration of adult-born neurons. We also discuss the regulation and potential functions of adult neurogenesis in physiological and pathological conditions.
引用
收藏
页码：2291 / 2299
页数：9
相关论文
共 50 条
  • [41] Neurogenesis disturbances in adult rats exposed to uranium during development
    Legrand, M.
    Elie, C.
    Culeux, C.
    Lestaevel, P.
    Dinocourt, C.
    TOXICOLOGY LETTERS, 2015, 238 (02) : S342 - S342
  • [42] Sequential development of synapses in dendritic domains during adult neurogenesis
    Kelsch, Wolfgang
    Lin, Chia-Wei
    Lois, Carlos
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (43) : 16803 - 16808
  • [43] Development of Circadian Oscillators in Neurosphere Cultures during Adult Neurogenesis
    Malik, Astha
    Jamasbi, Roudabeh J.
    Kondratov, Roman V.
    Geusz, Michael E.
    PLOS ONE, 2015, 10 (03):
  • [44] Neurogenesis in the adult brain: a hope for brain repair?
    Prochiantz, A
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2000, 184 (06): : 1181 - 1190
  • [45] Post-transcriptional regulation during adult neurogenesis and brain ageing
    Rolando, C.
    Erni, A.
    Ifflander, N.
    Taylor, V.
    GLIA, 2019, 67 : E86 - E86
  • [46] The role of cannabinoids in adult neurogenesis
    Prenderville, Jack A.
    Kelly, Aine M.
    Downer, Eric J.
    BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (16) : 3950 - 3963
  • [47] Astrocytes: a role in adult neurogenesis
    不详
    NEUROSCIENTIST, 2002, 8 (04): : 291 - 291
  • [48] The role of microglia in adult neurogenesis
    Reshef, R.
    Kudryavitskaya, E.
    Shani, H.
    Rimmerman, N.
    Mizrahi, A.
    Yirmiya, R.
    BRAIN BEHAVIOR AND IMMUNITY, 2016, 57 : E14 - E15
  • [49] The Role of PLAG1 in Mouse Brain Development and Neurogenesis
    Gasperoni, Jemma G.
    Tran, Stephanie C.
    Grommen, Sylvia V. H.
    De Groef, Bert
    Dworkin, Sebastian
    MOLECULAR NEUROBIOLOGY, 2024, 61 (08) : 5851 - 5867
  • [50] Adult Neurogenesis in the Development of Epilepsy
    Danzer, Steve C.
    EPILEPSY CURRENTS, 2019, 19 (05) : 316 - 320
12345