Coumarins from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities

被引：15

作者：

Liu, Chun-Bo ^{[1
]}

Shen, Qin-Peng ^{[1
]}

Wang, Yun ^{[1
,2
]}

Zhang, Feng-Mei ^{[1
]}

He, Pei ^{[1
]}

Si, Xiao-Xi ^{[1
]}

Wang, Kun-Miao ^{[1
]}

Zhu, Rui-Zhi ^{[1
]}

Xiang, Neng-Jun ^{[1
]}

Liu, Zhi-Hua ^{[1
]}

机构：

[1] China Tobacco Yunnan Ind Co Ltd, Ctr Res & Dev, Key Lab Tobacco Chem Yunnan Prov, Kunming 650231, Peoples R China

[2] Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2016年 / 52卷 / 06期

基金：

中国国家自然科学基金;

关键词：

coumarins; Nicotiana tabacum; anti-tobacco mosaic virus; PHENOLIC-COMPOUNDS; ORIENTAL TOBACCO; DERIVATIVES; ROOTS; STEMS; CYTOTOXICITY; FLAVONES;

D O I：

10.1007/s10600-016-1844-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new coumarins, 6-hydroxy-7-methyl-3-(4'-methoxyphenyl)-coumarin (1) and 6-hydroxy-5-methoxy-7-methyl-3-(4'-methoxyphenyl)-coumarin (2), together with five known coumarins (3-7), were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-7 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. Compound 2 showed high anti-TMV activity with inhibition rate of 28.6%. This rate is close to that of the positive control. The other compounds also showed potential anti-TMV activity with inhibition rates in the ranges of 13.7-23.2%, respectively.

引用

页码：992 / 995

页数：4

共 22 条

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