Current knowledge on the human eye microbiome: a systematic review of available amplicon and metagenomic sequencing data

被引：49

作者：

Delbeke, Heleen ^{[1
]}

Younas, Saif ^{[2
]}

Casteels, Ingele ^{[1
]}

Joossens, Marie ^{[3
]}

机构：

[1] Univ Hosp Leuven, Dept Ophthalmol, Herestr 49, B-3000 Leuven, Belgium

[2] Univ Hosp Leuven, Dept Internal Med, Leuven, Belgium

[3] Katholieke Univ Leuven, REGA Inst, Dept Mol Bacteriol, Leuven, Belgium

来源：

ACTA OPHTHALMOLOGICA | 2021年 / 99卷 / 01期

关键词：

ocular surface; eye; microbiome; microbiota; (16S rRNA) amplicon sequencing; OCULAR SURFACE MICROBIOTA; CONTACT-LENS; CONJUNCTIVAL MICROBIOME; DIVERSITY; IDENTIFICATION; COMMUNITIES; BACTERIA; DISEASE; HEALTH;

D O I：

10.1111/aos.14508

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Insights in the ocular surface microbiome are still at an early stage and many more questions remain unanswered compared with other human-associated microbial communities. The current knowledge on the human microbiome changed our viewpoint on bacteria and human health and significantly enhanced our understanding of human pathophysiology. Also in ocular medicine, microbiome research might impact treatment. Here, we summarize the current knowledge on ocular microbiome research with a particular focus on potential confounding factors and their effects on microbiome composition. Moreover, we present the ocular surface core microbiome based on current available data and defined it as genera present in almost half of the published control cohorts with a relative abundance of at least 1%.

引用

页码：16 / 25

页数：10

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