Nasopharyngeal carcinoma in children and young adults-Beyond 5-year survival

被引：18

作者：

Ben-Ami, Tal ^{[1
]}

Ash, Shifra ^{[2
]}

Ben-Harosh, Miri ^{[3
]}

Gavriel, Herzel ^{[4
]}

Weintraub, Michael ^{[5
]}

Revel-Vilk, Shoshana ^{[6
]}

Ben-Arush, Myriam ^{[7
]}

机构：

[1] Kaplan Med Ctr, Pediat Hematol Oncol Unit, Pasternak St, Rehovot, Israel

[2] Schneider Childrens Med Ctr Israel, Dept Pediat Hematol Oncol, Petah Tiqwa, Israel

[3] Soroka Med Ctr, Dept Pediat Hematol Oncol, Beer Sheva, Israel

[4] Haemek Med Ctr, Pediat Hematol Oncol Unit, Afula, Israel

[5] ALYN Hosp Pediat & Adolescent Rehabil Ctr, Pediat Oncol, Jerusalem, Israel

[6] Hadassah Hebrew Univ Med Sch, Pediat Hematol, Sharee Zedek Med Ctr, Jerusalem, Israel

[7] Rambam Hlth Care Campus, Ruth Rappaport Childrens Hosp, Div Pediat Hematol Oncol, Haifa, Israel

来源：

PEDIATRIC BLOOD & CANCER | 2020年 / 67卷 / 09期

关键词：

late toxicities; long-term follow up; nasopharyngeal carcinoma; second malignancies; CHILDHOOD; ADOLESCENTS;

D O I：

10.1002/pbc.28494

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nasopharyngeal carcinoma (NPC) is a rare and locally aggressive form of childhood cancer. Treatment of NPC includes chemotherapy and radiotherapy. With current treatment protocols, survival rates for patients with nonmetastatic disease is over 80%. Data regarding very late events including long-term treatment-related morbidities and second malignancies are scarce. We present our data on 42 patients with NPC treated in Israel between 1989 and 2014, and followed until 2019. During follow up, five patients had disease recurrence, and four children developed secondary malignancy. Median time to diagnosis of secondary malignancy was 105 months. Eighty-eight percent of patients have long-term treatment-related morbidities.

引用

页数：4

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