Growth hormone therapy in children; research and practice - A review

被引：53

作者：

Collett-Solberg, Paulo Ferrez ^{[1
]}

Jorge, Alexander A. L. ^{[2
]}

Boguszewski, Margaret C. S. ^{[3
]}

Miller, Bradley S. ^{[4
]}

Choong, Catherine Seut Yhoke ^{[5
]}

Cohen, Pinchas ^{[6
]}

Hoffman, Andrew R. ^{[7
]}

Luo, Xiaoping ^{[8
]}

Radovick, Sally ^{[9
]}

Saenger, Paul ^{[10
]}

机构：

[1] Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Med Interna, Pediat Endocrinol, Rio De Janeiro, RJ, Brazil

[2] FMUSP, Endocrinol Div, Genet Endocrinol Unit LIM 25, Sao Paulo, SP, Brazil

[3] Univ Fed Parana UFPR, Dept Pediat, Curitiba, Parana, Brazil

[4] Univ Minnesota, Masonic Childrens Hosp, Pediat Endocrinol, Minneapolis, MN 55455 USA

[5] Univ Western Australia, Perth Childrens Hosp, Sch Med, Div Pediat, Nedlands, WA, Australia

[6] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA USA

[7] Stanford Univ, Dept Med, Acad Affairs, Stanford, CA 94305 USA

[8] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pediat, Wuhan, Hubei, Peoples R China

[9] Univ Med & Dent New Jersey, Dept Pediat, Clin & Translat Res, New Brunswick, NJ USA

[10] NYU, Winthrop Hosp, 101 Mineola Blvd, Brooklyn, NY 11201 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2019年 / 44卷

关键词：

Short stature; Growth; Growth hormone; Genetic; IDIOPATHIC SHORT STATURE; SITTING HEIGHT/HEIGHT RATIO; IDENTIFY GENETIC CAUSES; FOR-GESTATIONAL-AGE; FACTOR-I TREATMENT; B NPR2 GENE; COST-EFFECTIVENESS; HETEROZYGOUS MUTATIONS; DIAGNOSTIC-VALUE; 2ND NEOPLASMS;

D O I：

10.1016/j.ghir.2018.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Short stature remains the most common reason for referral to a pediatric Endocrinologist and its management remains a challenge. One of the main controversies is the diagnosis of idiopathic short stature and the role of new technologies for genetic investigation of children with inadequate growth. Complexities in management of children with short stature includes selection of who should receive interventions such as recombinant human growth hormone, and how should this agent dose be adjusted during treatment. Should anthropometrical data be the primary determinant or should biochemical and genetic data be used to improve growth response and safety? Furthermore, what is considered a suboptimal response to growth hormone therapy and how should this be managed? Treatment of children with short stature remains a "hot" topic and more data is needed in several areas. These issues are reviewed in this paper.

引用

页码：20 / 32

页数：13

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