Stearoyl-CoA desaturase-1 inhibitors: Discovery and in vivo evaluation

被引:0
|
作者
Liu, Gang
Xin, Zhili
Zhao, Hongyu
Serby, Michael D.
Smith, Harriet T.
Cao, Ning [1 ]
Surowy, Teresa K.
Adler, Andrew [1 ]
Mika, Amanda [1 ]
Farb, Thomas B.
Keegan, Cheryl [1 ]
Landschulz, Kathy [1 ]
Brune, Michael [2 ]
Collins, Christine A.
Sham, Hing L.
Camp, Heidi S.
机构
[1] Abbott Labs, Global Pharmaceut Res & Dev, Metab Dis Res, Abbott Pk, IL 60064 USA
[2] Abbott Labs, Global Pharmaceut Res Div, Metab Dis Res, Abbott Pk, IL 60064 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
232-MEDI
引用
收藏
页码:525 / 525
页数:1
相关论文
共 50 条
  • [31] Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    Ntambi, JM
    Miyazaki, M
    Stoehr, JP
    Lan, H
    Kendziorski, CM
    Yandell, BS
    Song, Y
    Cohen, P
    Friedman, JM
    Attie, AD
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (17) : 11482 - 11486
  • [32] Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions
    Breuer, S
    Pech, K
    Buss, A
    Spitzer, C
    Ozols, J
    Hol, EM
    Heussen, N
    Noth, J
    Schwaiger, FW
    Schmitt, AB
    BMC NEUROSCIENCE, 2004, 5 (1)
  • [33] Stearoyl-CoA Desaturase-1 Is Associated with Insulin Resistance in Morbidly Obese Subjects
    Sara García-Serrano
    Inmaculada Moreno-Santos
    Lourdes Garrido-Sánchez
    Carolina Gutierrez-Repiso
    Jose M. García-Almeida
    Juan García-Arnés
    Jose Rivas-Marín
    Jose L. Gallego-Perales
    Eva García-Escobar
    Gemma Rojo-Martinez
    Francisco Tinahones
    Federico Soriguer
    Manuel Macias-Gonzalez
    Eduardo García-Fuentes
    Molecular Medicine, 2011, 17 : 273 - 280
  • [34] Leptin and the control of metabolism: Role for stearoyl-CoA desaturase-1 (SCD-1)
    Cohen, P
    Friedman, JM
    JOURNAL OF NUTRITION, 2004, 134 (09): : 2455S - 2463S
  • [35] Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells
    Thon, Mina
    Hosoi, Toru
    Chea, Chanbora
    Ozawa, Koichiro
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2017, 40 (08) : 1161 - 1164
  • [36] Role of dietary trans fatty acids in the regulation of stearoyl-CoA desaturase-1 enzyme
    Tibori, K.
    Csala, M.
    Kereszturi, E.
    FEBS OPEN BIO, 2024, 14 : 390 - 390
  • [37] THE REGULATION OF STEAROYL-COA DESATURASE-1 GENE BY PEROXISOME PROLIFERATORS IN MOUSE-LIVER
    MILLER, CW
    NTAMBI, JM
    FASEB JOURNAL, 1995, 9 (06): : A1366 - A1366
  • [38] Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells
    A Noto
    S Raffa
    C De Vitis
    G Roscilli
    D Malpicci
    P Coluccia
    A Di Napoli
    A Ricci
    M R Giovagnoli
    L Aurisicchio
    M R Torrisi
    G Ciliberto
    R Mancini
    Cell Death & Disease, 2013, 4 : e947 - e947
  • [39] Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance
    Sampath, Harini
    Ntambi, James M.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (05) : 2482 - 2488
  • [40] Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors
    Xin, Zhili
    Zhao, Hongyu
    Serby, Michael D.
    Liu, Bo
    Liu, Mei
    Szczepankiewicz, Bruce G.
    Nelson, Lissa T. J.
    Smith, Harriet T.
    Suhar, Tom S.
    Janis, Rich S.
    Cao, Ning
    Camp, Heidi S.
    Collins, Christine A.
    Sham, Hing L.
    Surowy, Teresa K.
    Liu, Gang
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (15) : 4298 - 4302