Rehmannia inhibits adipocyte differentiation and adipogenesis

被引：21

作者：

Jiang, Lin ^{[1
]}

Zhang, Nai-xian ^{[1
]}

Mo, Wei ^{[1
]}

Wan, Rui ^{[1
]}

Ma, Chun-gu ^{[1
]}

Li, Xi ^{[1
]}

Gu, Yin-liang ^{[1
]}

Yang, Xin-ying ^{[1
]}

Tang, Qi-qun ^{[1
]}

Song, Hou-yan ^{[1
]}

机构：

[1] Fudan Univ, Minist Educ, Key Lab Mol Med, Shanghai 200032, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 371卷 / 02期

关键词：

Rehmannia glutinosa; 3T3-L1; adipocyte differentiation; adipogenesis;

D O I：

10.1016/j.bbrc.2008.03.129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rehmannia glutinosa, a Traditional Chinese Medicine (TCM), has been used to increase physical strength. Here, we report that Rehmannia glutinosa extract (RE) inhibits adipocyte differentiation and adipogenesis. RE impairs differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. At the molecular level, treatment with RE inhibits expression of the key adipocyte differentiation regulator C/EBP beta, as well as C/EBP alpha and the terminal marker protein 422/aP2, during differentiation of preadipocytes into adipocytes. Additionally, RE inhibits the mitotic clonal expansion (MCE) process of adipocyte differentiation, and RE prevents localization of C/EBP beta to the centromeres. RE also prevents high fat diet (HFD) induced weight gain and adiposity in rats. Taken together, our results indicate that Rehmannia glutinosa extract inhibits preadipocyte differentiation and adipogenesis in cultured cells and in rodent models,of obesity. (C) 2008 Published by Elsevier Inc.

引用

页码：185 / 190

页数：6

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