A mesenchymal chondrosarcoma with aberrant nuclear expression of STAT6: a potential diagnostic pitfall

被引：4
|
作者：
Broggi, Giuseppe [1 ]
Mazzucchelli, Manuel [1 ]
Covello, Renato [2 ]
Casini, Beatrice [2 ]
Broggi, Giuseppe Maria Vincenzo [3 ,4 ]
Salvatorelli, Lucia [1 ]
Magro, Gaetano [1 ]
机构：
[1] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Anat Pathol, I-95123 Catania, Italy
[2] Regina Elena Natl Canc Inst IRCCS, Pathol Dept, I-00168 Rome, Italy
[3] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Neurol Surg, Policlin Rodolico San Marco Univ Hosp, I-95123 Catania, Italy
[4] Univ Catania, Interdisciplinary Res Ctr Diag & Therapy Brain Tu, I-95123 Catania, Italy
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2022年 / 232卷
关键词：
Mesenchymal chondrosarcoma; STAT6; HEY1-NCOA2 fusion gene; NAB2-STAT6 fusion gene; Diagnostic pitfall; SOLITARY FIBROUS TUMOR; IMMUNOHISTOCHEMISTRY; FUSION;
D O I：
10.1016/j.prp.2022.153803
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
STAT6 is usually considered to be a very sensitive and specific immunomarker for diagnosis of solitary fibrous tumor (SFT), being a surrogate of the NAB2-STAT6 fusion gene identified in most cases of this tumor. STAT6 expression has also been reported in rare cases of other soft tissue tumors, such as low-grade fibromyxoid sar -coma, myxoid/round cell liposarcoma, dedifferentiated liposarcoma and deep fibrous histiocytoma. The aim of this study was to report, for the first time, a case of mesenchymal chondrosarcoma showing diffuse aberrant immunohistochemical expression of STAT6. Molecular biology, showing the HEY1-NCOA2 fusion gene, was crucial to rule out SFT.
引用
收藏
页数：4
相关论文
共 50 条
  • [31] Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour
    Koelsche, Christian
    Schweizer, Leonille
    Renner, Marcus
    Warth, Arne
    Jones, David T. W.
    Sahm, Felix
    Reuss, David E.
    Capper, David
    Knoesel, Thomas
    Schulz, Birte
    Petersen, Iver
    Ulrich, Alexis
    Renker, Eva Kristin
    Lehner, Burkhard
    Pfister, Stefan M.
    Schirmacher, Peter
    von Deimling, Andreas
    Mechtersheimer, Gunhild
    HISTOPATHOLOGY, 2014, 65 (05) : 613 - 622
  • [32] Aberrant Expression of Pneumocytic Markers (TTF-1 and Napsin-A) in Biliary Duct and Gallbladder Adenocarcinomas; A Potential Diagnostic Pitfall
    Khedkar, Rutvij
    Agrawal, Radhika
    Yadav, Subhash
    Kaushal, Rajiv Kumar
    INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2024, : 661 - 665
  • [33] CD31 expression in intratumoral macrophages - A potential diagnostic pitfall
    McKenney, JK
    Weiss, SW
    Folpe, AL
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (09) : 1167 - 1173
  • [34] Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining
    Magro, Gaetano
    Angelico, Giuseppe
    Leone, Giorgia
    Palazzo, Juan
    PATHOLOGY RESEARCH AND PRACTICE, 2016, 212 (05) : 463 - 467
  • [35] TRPS1 Expression Is Frequently Seen in a Subset of Cutaneous Mesenchymal Neoplasms and Tumors of Uncertain Differentiation: A Potential Diagnostic Pitfall
    Kim, Moon Joo
    Liu, Yi A.
    Wang, Yunyi
    Ning, Jing
    Cho, Woo Cheal
    DERMATOPATHOLOGY, 2024, 11 (03): : 200 - 208
  • [36] Variability of CD34 Expression in Sinonasal Glomangiopericytoma: A Potential Diagnostic Pitfall
    Ankur R. Sangoi
    Justin A. Bishop
    Head and Neck Pathology, 2020, 14 : 459 - 464
  • [37] GATA3 Expression in Prostatic Adenosquamous Carcinoma: A Potential Diagnostic Pitfall
    Potterveld, Susan K.
    Williamson, Sean R.
    Al-Obaidy, Khaleel I.
    Akgul, Mahmut
    Chan, Emily
    Giannico, Giovanna A.
    Sangoi, Ankur R.
    INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2025, 33 (01) : 85 - 91
  • [38] Expression of Sox-9 in Metastatic Melanoma-A Potential Diagnostic Pitfall
    Rao, Priya
    Fuller, Gregory N.
    Prieto, Victor G.
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2010, 32 (03) : 262 - 266
  • [39] Melan-A expression in non-melanocytic carcinoma: A potential diagnostic pitfall
    Zuo, Linwei
    You, Huiyan
    Cai, Zhe
    Liao, Shousheng
    Lu, Xiangtong
    Li, Lixiang
    Huang, Wenyong
    HISTOLOGY AND HISTOPATHOLOGY, 2024, 39 (08) : 1037 - 1041
  • [40] Expression of terminal deoxynucleotidyl transferase (TdT) in classical seminoma: a potential diagnostic pitfall
    Brobeil, Alexander
    Wagenlehner, Florian
    Gattenloehner, Stefan
    VIRCHOWS ARCHIV, 2018, 472 (03) : 433 - 440
12345