A mesenchymal chondrosarcoma with aberrant nuclear expression of STAT6: a potential diagnostic pitfall

被引：4

作者：

Broggi, Giuseppe ^{[1
]}

Mazzucchelli, Manuel ^{[1
]}

Covello, Renato ^{[2
]}

Casini, Beatrice ^{[2
]}

Broggi, Giuseppe Maria Vincenzo ^{[3
,4
]}

Salvatorelli, Lucia ^{[1
]}

Magro, Gaetano ^{[1
]}

机构：

[1] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Anat Pathol, I-95123 Catania, Italy

[2] Regina Elena Natl Canc Inst IRCCS, Pathol Dept, I-00168 Rome, Italy

[3] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Neurol Surg, Policlin Rodolico San Marco Univ Hosp, I-95123 Catania, Italy

[4] Univ Catania, Interdisciplinary Res Ctr Diag & Therapy Brain Tu, I-95123 Catania, Italy

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2022年 / 232卷

关键词：

Mesenchymal chondrosarcoma; STAT6; HEY1-NCOA2 fusion gene; NAB2-STAT6 fusion gene; Diagnostic pitfall; SOLITARY FIBROUS TUMOR; IMMUNOHISTOCHEMISTRY; FUSION;

D O I：

10.1016/j.prp.2022.153803

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

STAT6 is usually considered to be a very sensitive and specific immunomarker for diagnosis of solitary fibrous tumor (SFT), being a surrogate of the NAB2-STAT6 fusion gene identified in most cases of this tumor. STAT6 expression has also been reported in rare cases of other soft tissue tumors, such as low-grade fibromyxoid sar -coma, myxoid/round cell liposarcoma, dedifferentiated liposarcoma and deep fibrous histiocytoma. The aim of this study was to report, for the first time, a case of mesenchymal chondrosarcoma showing diffuse aberrant immunohistochemical expression of STAT6. Molecular biology, showing the HEY1-NCOA2 fusion gene, was crucial to rule out SFT.

引用

页数：4

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