Small-Cell Lung Cancer in Never-Smokers: A Case Series With Information on Family History of Cancer and Environmental Tobacco Smoke

被引：24

作者：

Kurahara, Yu ^{[1
]}

Kawaguchi, Tomoya ^{[1
]}

Tachibana, Kazunobu ^{[1
]}

Atagi, Shinji ^{[1
]}

Hayashi, Seiji ^{[1
]}

Kitaichi, Masanori ^{[2
]}

Ou, Sai-Hong I. ^{[3
]}

Takada, Minoru ^{[4
]}

机构：

[1] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Internal Med, Sakai, Osaka 5918555, Japan

[2] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Pathol, Sakai, Osaka 5918555, Japan

[3] Univ Calif Irvine, Irvine Med Ctr, Dept Med, Div Hematol Oncol,Chao Family Comprehens Canc Ctr, Orange, CA 92668 USA

[4] Kinki Univ, Fac Med, Dept Med Oncol, Sakai Hosp, Osaka, Japan

来源：

CLINICAL LUNG CANCER | 2012年 / 13卷 / 01期

关键词：

EGFR mutation; Environmental tobacco smoke; Family history of cancer; K-ras mutation; Small-cell lung cancer; FACTOR RECEPTOR MUTATIONS; HISTOLOGIC TYPE; RISK;

D O I：

10.1016/j.cllc.2011.04.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small-cell lung cancer (SCLC) is closely associated with smoking, but there has been little attention given to never-smokers. The potential causative factors of a family history of cancers (FHC) and environmental tobacco smoke (ETS) have not been described in previous reports. We retrospectively reviewed the clinical files of 271 consecutive SCLC patients who were newly diagnosed in Kinki-Chuo Chest Medical Center, Japan, from January 2004 through July 2010, and identified four cases (1.5%) who were never-smokers. They were all females and had an FHC with exposure to ETS. One patient had both epidermal growth factor receptor (EGFR) and K-ras mutations. FHC and ETS provide a potential clue to clarify the development of SCLC in never-smokers. Further research will be needed to better understand the potential role of molecular alterations in the pathogenesis of small-cell carcinoma.

引用

页码：75 / 79

页数：5

共 23 条

[1] Small-Cell Carcinoma With an Epidermal Growth Factor Receptor Mutation in a Never-Smoker With Gefitinib-Responsive Adenocarcinoma of the Lung [J].

Alam, Naheed ;

Gustafson, Karen S. ;

Ladanyi, Marc ;

Zakowski, Maureen F. ;

Kapoor, Atul ;

Truskinovsky, Alexander M. ;

Dudek, Arkadiusz Z. .

CLINICAL LUNG CANCER, 2010, 11 (05) :E1-E4

[2] Second-hand smoke and human lung cancer [J].

Besaratinia, Ahmad ;

Pfeifer, Gerd P. .

LANCET ONCOLOGY, 2008, 9 (07) :657-666

[3] GENDER AND HISTOLOGIC TYPE VARIATIONS IN SMOKING-RELATED RISK OF LUNG-CANCER [J].

BROWNSON, RC ;

CHANG, JC ;

DAVIS, JR .

EPIDEMIOLOGY, 1992, 3 (01) :61-64

[4] Characteristics of never smoker lung cancer including environmental and occupational risk factors [J].

Clement-Duchene, Christelle ;

Vignaud, Jean-Michel ;

Stoufflet, Audrey ;

Bertrand, Odile ;

Gislard, Antoine ;

Thiberville, Luc ;

Grosdidier, Gilles ;

Martinet, Yves ;

Benichou, Jacques ;

Hainaut, Pierre ;

Paris, Christophe .

LUNG CANCER, 2010, 67 (02) :144-150

[5]

DAVID JS, 2007, CHEST, V132, pS314

[6] Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer [J].

Gao, Ying ;

Goldstein, Alisa M. ;

Consonni, Dario ;

Pesatori, Angela C. ;

Wacholder, Sholom ;

Tucker, Margaret A. ;

Caporaso, Neil E. ;

Goldin, Lynn ;

Landi, Maria Teresa .

INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (01) :146-152

[7]

GEORGE K, 2010, J THORAC ONCOL, V5, P747

[8] Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database [J].

Govindan, Ramaswamy ;

Page, Nathan ;

Morgensztern, Daniel ;

Read, William ;

Tierney, Ryan ;

Vlahiotis, Anna ;

Spitznagel, Edward L. ;

Piccirillo, Jay .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (28) :4539-4544

[9]

HAEDER M, 1988, CANCER RES, V48, P1132

[10] The Applicability of the Proposed IASLC Staging Revisions to Small Cell Lung Cancer (SCLC) with Comparison to the Current UICC 6th TNM Edition [J].

Ou, Sai-Hong Ignatius ;

Zell, Jason A. .

JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (03) :300-310

← 1 2 3 →