Proteomics of corynebacteria: From biotechnology workhorses to pathogens

被引:18
作者
Poetsch, Ansgar [2 ]
Haussmann, Ute [2 ]
Burkovski, Andreas [1 ]
机构
[1] Univ Erlangen Nurnberg, Lehrstuhl Mikrobiol, D-91058 Erlangen, Germany
[2] Ruhr Univ Bochum, Lehrstuhl Biochem Pflanzen, Bochum, Germany
关键词
Corynebacterium diphtheriae; Corynebacterium glutamicum; Microbiology; Mycobacterium; TRANSCRIPTIONAL REPRESSOR MCBR; ARGININE TRANSLOCATION PATHWAY; INTEGRAL MEMBRANE-PROTEINS; LYSINE-PRODUCING STRAIN; AMINO-ACIDS; GLUTAMICUM ATCC-13032; CELL-SURFACE; NITROGEN REGULATION; OXIDATIVE STRESS; REFERENCE MAP;
D O I
10.1002/pmic.201000786
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Corynebacteria belong to the high G+C Gram-positive bacteria (Actinobacteria) and are closely related to Mycobacterium and Nocardia species. The best investigated member of this group of almost seventy species is Corynebacterium glutamicum, a soil bacterium isolated in 1957, which is used for the industrial production of more than two million tons of amino acids per year. This review focuses on the technical advances made in proteomics approaches during the last years and summarizes applications of these techniques with respect to C. glutamicum metabolic pathways and stress response. Additionally, selected proteome applications for other biotechnologically important or pathogenic corynebacteria are described.
引用
收藏
页码:3244 / 3255
页数:12
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