Halitulin, a new cytotoxic alkaloid from the marine sponge Haliclona tulearensis

被引：83

作者：

Kashman, Y ^{[1
]}

Koren-Goldshlager, G

Gravalos, G

Schleyer, M

机构：

[1] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel

[2] PharmaMar SA, Madrid, Spain

[3] Oceanog Inst, Durban, South Africa

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(98)02467-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Halitulin (2), a novel bisquinolinylpyrrole has been isolated from the sponge Haliclona tulearensis. Its structure was elucidated mainly on the basis of spectroscopic data as well as chemical modifications. Halitulin was found to be cytotoxic against several tumor cells: P-388, A-549, HT-29 and MEL-28 in concentrations of 12-25 ng/ml. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：997 / 1000

页数：4

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