Letter to the Editor: Human Pluripotent Stem Cells Release Oncogenic Soluble E-Cadherin

被引:2
|
作者
Rosner, Margit [1 ]
Hengstschlager, Markus [1 ]
机构
[1] Med Univ Vienna, Inst Med Genet, Ctr Pathobiochem & Genet, Vienna, Austria
关键词
Human pluripotent stem cells; Oncogenic soluble E-cadherin; Paracrine signaling; Stem cell-based therapy; ADHESION;
D O I
10.1002/stem.2461
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Since their discovery, human pluripotent stem cells (hPSCs) including embryonic and induced pluripotent stem cells hold great promise in disease modeling and regenerative medicine. Despite intensive research and remarkable progress, it is becoming increasingly acknowledged that their yet incomplete, biological characterisation represents one of the major drawbacks to their successful translation into the clinics. The expression of the transmembrane protein E-cadherin in hPSCs is well defined to be pivotal to the maintenance of the pluripotent state by mediating intercellular adhesion and intracellular signaling. Next to these canonical functions, were here report for the first time that hPSCs are subject to matrix metalloproteinase-dependent E-cadherin ectodomain shedding. This generates a similar to 80-kD, soluble E-cadherin fragment which is released into the extracellular space, and which is well described to exert paracrine signaling activity and classified as being oncogenic. Collectively, this finding does not only improve our knowledge on the signaling crosstalk between hPSCs and their cellular environment and the type and nature of the paracrine signals produced by these cells, but also has clear implications for the development of efficient and safe stem cell-based therapies.
引用
收藏
页码:2443 / 2446
页数:4
相关论文
共 50 条
  • [31] E-cadherin expression in human melanoma
    Danen, EHJ
    deVries, TJ
    Morandini, R
    Ghanem, GG
    Ruiter, DJ
    vanMuijen, GNP
    MELANOMA RESEARCH, 1996, 6 (02) : 127 - 131
  • [32] Truncated vitronectin with E-cadherin enables the xeno-free derivation of human embryonic stem cells
    Souralova, Tereza
    Hulinova, Daniela
    Jeseta, Michal
    Ventruba, Pavel
    Hampl, Ales
    Koutna, Irena
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [33] E-cadherin distribution in the human conjunctiva
    Scott, RAH
    Lauweryns, B
    PowellRichards, A
    Tighe, P
    Gormley, PD
    Spencer, AF
    Dua, HS
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 1652 - 1652
  • [34] Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase
    Schmidt, CR
    Washington, MK
    Gi, YJ
    Coffey, RJ
    Beauchamp, RD
    Pearson, AS
    AMERICAN JOURNAL OF SURGERY, 2003, 186 (05): : 426 - 430
  • [35] Dissecting the Oncogenic and Tumorigenic Potential of Differentiated Human Induced Pluripotent Stem Cells and Human Embryonic Stem Cells
    Ghosh, Zhumur
    Huang, Mei
    Hu, Shijun
    Wilson, Kitchener D.
    Dey, Devaveena
    Wu, Joseph C.
    CANCER RESEARCH, 2011, 71 (14) : 5030 - 5039
  • [36] The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells
    Tsao, SW
    Liu, Y
    Wang, XH
    Yuen, PW
    Leung, SY
    Yuen, ST
    Pan, J
    Nicholls, JM
    Cheung, ALM
    Wong, YC
    EUROPEAN JOURNAL OF CANCER, 2003, 39 (04) : 524 - 531
  • [37] Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin
    Malaguti, Mattias
    Nistor, Paul A.
    Blin, Guillaume
    Pegg, Amy
    Zhou, Xinzhi
    Lowell, Sally
    ELIFE, 2013, 2
  • [38] Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance toModels of Tumorigenesis
    Mohamet, Lisa
    Hawkins, Kate
    Ward, Christopher M.
    JOURNAL OF ONCOLOGY, 2011, 2011
  • [39] Effects of E-Cadherin on Embryonic Stem Cells Differentiating into Hepatic Tissue In Vitro
    Hu, Anbin
    He, Xiaoshun
    Zhu, Xiaofeng
    LIVER TRANSPLANTATION, 2011, 17 (06) : S140 - S140
  • [40] The Construction of E-Cadherin Lentivirus Vectors and the Experimental Study of E-Cadherin on Neural Stem Cell Biological Behavior
    Liu, Jie
    Chen, Dong
    Li, Shao-Hua
    Shi, Yong-Zhen
    Wu, Zhong
    Qian, Wei-Qiang
    Huang, Xiang
    Li, Zhen-Hua
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2016, 6 (05) : 349 - 361