Letter to the Editor: Human Pluripotent Stem Cells Release Oncogenic Soluble E-Cadherin

被引:2
|
作者
Rosner, Margit [1 ]
Hengstschlager, Markus [1 ]
机构
[1] Med Univ Vienna, Inst Med Genet, Ctr Pathobiochem & Genet, Vienna, Austria
关键词
Human pluripotent stem cells; Oncogenic soluble E-cadherin; Paracrine signaling; Stem cell-based therapy; ADHESION;
D O I
10.1002/stem.2461
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Since their discovery, human pluripotent stem cells (hPSCs) including embryonic and induced pluripotent stem cells hold great promise in disease modeling and regenerative medicine. Despite intensive research and remarkable progress, it is becoming increasingly acknowledged that their yet incomplete, biological characterisation represents one of the major drawbacks to their successful translation into the clinics. The expression of the transmembrane protein E-cadherin in hPSCs is well defined to be pivotal to the maintenance of the pluripotent state by mediating intercellular adhesion and intracellular signaling. Next to these canonical functions, were here report for the first time that hPSCs are subject to matrix metalloproteinase-dependent E-cadherin ectodomain shedding. This generates a similar to 80-kD, soluble E-cadherin fragment which is released into the extracellular space, and which is well described to exert paracrine signaling activity and classified as being oncogenic. Collectively, this finding does not only improve our knowledge on the signaling crosstalk between hPSCs and their cellular environment and the type and nature of the paracrine signals produced by these cells, but also has clear implications for the development of efficient and safe stem cell-based therapies.
引用
收藏
页码:2443 / 2446
页数:4
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