Targeted and armed oncolytic adenovirus via chemoselective modification

被引：11
作者：
Banerjee, Partha S.
Zuniga, Edison S.
Ojima, Iwao
Carrico, Isaac S.
机构：
[1] SUNY Stony Brook, Inst Chem Biol & Drug Discovery, Stony Brook, NY 11790 USA
[2] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11790 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 17期
关键词：
Non-canonical; Unnatural; Chemoselective; Click; Staudinger; Adenovirus; Taxoid; Paclitaxel; Oncolytic; Gene delivery; HERPES-SIMPLEX-VIRUS; CANCER; EFFICACY; PACLITAXEL; PROTEINS; DELIVERY; CELLS;
D O I：
10.1016/j.bmcl.2011.05.039
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification. (C) 2011 Elsevier Ltd. All rights reserved.
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收藏
页码：4985 / 4988
页数：4
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