Kinetics and mechanism of oxidation of chloramphenicol by 1-chlorobenzotriazole in acidic medium

被引：11

作者：

Hiremath, RC ^{[1
]}

Jagadeesh, RV ^{[1
]}

Puttaswamy ^{[1
]}

Mayanna, SM ^{[1
]}

机构：

[1] Bangalore Univ, Dept Postgrad Studies & Res Chem, Bangalore 560001, Karnataka, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2005年 / 117卷 / 04期

关键词：

chloramphenicol; 1-chlorobenzotriazole; oxidation; kinetics;

D O I：

10.1007/BF02708447

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chloramphenicol (CAP) is an,antibiotic drug having a wide spectrum of activity. The kinetics of oxidation of chloramphenicol by I-chlorobenzotriazole (CBT) in HClO4 medium over the temperature range 293-323 K has been investigated. The reaction exhibits first-order kinetics with respect to [CBT](o) and zero-order with respect to [CAP](o). The fractional-order dependence of rate on [H+] suggests complex formation between CBT and H+. It fails to induce polymerization of acrylonitrile under the experimental conditions employed. Activation parameters are evaluated. The observed solvent isotope effect indicates the absence of hydride transfer during oxidation. Effects of dielectric constant and ionic strength of the medium on the reaction rate have been studied. Oxidation products are identified. A suitable reaction scheme is proposed and an appropriate rate law is deduced to account for the observed kinetic data.

引用

页码：333 / 336

页数：4

共 17 条

[1]

Amis E.S, 1966, Solvent Effects on Reaction Rates and Mechanisms

[2]

COLLINS CJ, 1970, ISOTOPE EFFECTS CHEM, P267

[3]

GALSTYAN GA, 1990, UKR UKNIN ZH, V42, P738

[4]

HIREMATH RC, 1984, MIKROCHIM ACTA, V2, P175

[5]

Hiremath RC, 2003, OXID COMMUN, V26, P574

[6]

HIREMATH RC, 1990, J SCI IND RES INDIA, V49, P122

[7]

HUGHES ED, 1952, Q REV, P6

[8] OXIDIMETRIC ESTIMATION OF CHLORAMPHENICOL WITH AROMATIC SULFONYL MONOHALOAMINES [J].

JAYARAM, B ;

MAYANNA, SM .

TALANTA, 1983, 30 (10) :798-800

[9]

JOHNSON CR, 1972, TETRAHEDRON LETT, P501

[10]

Nanda N, 1999, INT J CHEM KINET, V31, P153, DOI 10.1002/(SICI)1097-4601(1999)31:2<153::AID-KIN8>3.3.CO

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