Role and classification of cholesterol-lowering functional foods

被引：152
作者：
Chen, Zhen-Yu [1 ]
Ma, Ka Ying [1 ]
Liang, Yintong [1 ]
Peng, Cheng [1 ]
Zuo, Yuanyuan [1 ]
机构：
[1] Chinese Univ Hong Kong, Sch Life Sci, Food & Nutr Sci Programme, Shatin, Hong Kong, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2011年 / 3卷 / 02期
关键词：
ACAT; CETP; Cholesterol; HDL; HMG-CoA reductase; LDL; Lipoproteins; Nutraceuticals; NPC1L1; ESTER TRANSFER PROTEIN; HMG-COA REDUCTASE; LDL-RECEPTOR ACTIVITY; COENZYME-A REDUCTASE; PLASMA-CHOLESTEROL; MESSENGER-RNA; DIETARY-CHOLESTEROL; SERUM-CHOLESTEROL; GENE-EXPRESSION; HAWTHORN FRUIT;
D O I：
10.1016/j.jff.2011.02.003
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Cholesterol is always an issue because blood total cholesterol (TC) and low-density lipoprotein (LDL) correlate strongly with coronary heart disease. Cholesterol homeostasis is maintained by a complex mechanism of sterol absorption, anabolism, catabolism and excretion. Nutraceuticals and functional foods which lower TC must affect the genes which regulate cholesterol homeostasis. In general, cholesterol-lowering functional foods and nutraceuticals can be classified into seven types namely intestinal Niemann-Pick Cl like 1 (NPC1L1) competitors, intestinal acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors, 3-hydroxy-3-methylglutaryl (HMG-CoA) reductase inhibitors, LDL receptor up-regulators, bile acid reabsorption inhibitors, cholesterol-7 alpha-hydroxylase (CYP7A1) activators, and plasma cholesteryl ester transporting protein (CETP) inhibitors. This mini-review classifies the popular cholesterol-lowering nutraceuticals and functional foods, and explores their underlying mechanisms. (C) 2011 Elsevier Ltd. All rights reserved.
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收藏
页码：61 / 69
页数：9
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