An lncRNA switch for AMPK activation

被引:26
作者
Liu, Xiaowen [1 ]
Xiao, Zhen-Dong [1 ]
Gan, Boyi [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Zayed Bldg Z7-3034,6565 MD Anderson Blvd, Houston, TX 77030 USA
关键词
autophagy; AMPK; energy stress response; lncRNA; LKB1; mTOR; NBR2; tumor suppression; ENERGY; PHOSPHORYLATION; AUTOPHAGY; ULK1;
D O I
10.1080/15384101.2016.1184515
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:1948 / 1949
页数:2
相关论文
共 7 条
[1]   Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy [J].
Egan, Daniel F. ;
Shackelford, David B. ;
Mihaylova, Maria M. ;
Gelino, Sara ;
Kohnz, Rebecca A. ;
Mair, William ;
Vasquez, Debbie S. ;
Joshi, Aashish ;
Gwinn, Dana M. ;
Taylor, Rebecca ;
Asara, John M. ;
Fitzpatrick, James ;
Dillin, Andrew ;
Viollet, Benoit ;
Kundu, Mondira ;
Hansen, Malene ;
Shaw, Reuben J. .
SCIENCE, 2011, 331 (6016) :456-461
[2]   AMPK-Sensing Energy while Talking to Other Signaling Pathways [J].
Hardie, D. Grahame .
CELL METABOLISM, 2014, 20 (06) :939-952
[3]   AMPK: a nutrient and energy sensor that maintains energy homeostasis [J].
Hardie, D. Grahame ;
Ross, Fiona A. ;
Hawley, Simon A. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (04) :251-262
[4]   AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 [J].
Kim, Joungmok ;
Kundu, Mondira ;
Viollet, Benoit ;
Guan, Kun-Liang .
NATURE CELL BIOLOGY, 2011, 13 (02) :132-U71
[5]   LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress [J].
Liu, Xiaowen ;
Xiao, Zhen-Dong ;
Han, Leng ;
Zhang, Jiexin ;
Lee, Szu-Wei ;
Wang, Wenqi ;
Lee, Hyemin ;
Zhuang, Li ;
Chen, Junjie ;
Lin, Hui-Kuan ;
Wang, Jing ;
Liang, Han ;
Gan, Boyi .
NATURE CELL BIOLOGY, 2016, 18 (04) :431-+
[6]   The AMPK signalling pathway coordinates cell growth, autophagy and metabolism [J].
Mihaylova, Maria M. ;
Shaw, Reuben J. .
NATURE CELL BIOLOGY, 2011, 13 (09) :1016-1023
[7]   Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene [J].
Xu, CF ;
Brown, MA ;
Nicolai, H ;
Chambers, JA ;
Griffiths, BL ;
Solomon, E .
HUMAN MOLECULAR GENETICS, 1997, 6 (07) :1057-1062