Plasminogen activator/plasmin system suppresses cell-cell adhesion of oral squamous cell carcinoma cells via proteolysis of E-cadherin

被引：2
作者：
Hayashido, Y [1 ]
Hamana, T [1 ]
Yoshioka, Y [1 ]
Kitano, H [1 ]
Koizumi, KI [1 ]
Okamoto, T [1 ]
机构：
[1] Hiroshima Univ, Grad Sch Biomed Sci, Div Frontier Med Sci, Dept Mol Oral Med & Maxillofacial Surg,Minami Ku, Hiroshima 7348553, Japan
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2005年 / 27卷 / 03期
关键词：
E-cadherin; squamous cell carcinoma; plasminogen activator/plasmin system; cell-cell adhesion; motility;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The participation of plasminogen activator/plasmin system in the expression and function of E-cadherin was examined in oral squamous cell carcinoma (SCC) cells. Treatment of SCC cells with plasminogen reduced the Ca2+-dependent cell aggregation. SCC cells expressed E-cadherin at the cell membrane, and released a small amount of soluble E-cadherin at 80 kDa in the culture medium. Addition of plasminogen to SCC cells led to a decrease in the amount of E-cadherin of the cell membrane and the enhancement of the shedding of E-cadherin ectodomain. Plasmin directly cleaved E-cadherin of SCC cells and enhanced the motility of SCC cells. These results suggested that plasminogen activator/plasmin system might directly mediate the proteolytic processing of E-cadherin in oral SCC cells and that might facilitate the progression of oral SCC by downregulation of E-cadherin-mediated cell-cell adhesion.
引用
收藏
页码：693 / 698
页数：6
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