Complexation of the sunscreen agent, butyl-methoxydibenzoylmethane, with hydroxypropyl-β-cyclodextrin.

被引：42

作者：

Scalia, S

Villani, S

Scatturin, A

Vandelli, MA

Forni, F

机构：

[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy

[2] Univ Modena, Dipartimento Sci Farmaceut, I-41100 Modena, Italy

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 175卷 / 02期

关键词：

butyl-methoxydibenzoylmethane; complex characterization; hydroxypropyl-beta-cyclodextrin; inclusion complexation; photodegradation;

D O I：

10.1016/S0378-5173(98)00283-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction between the sunscreen, butyl-methoxydibenzoylmethane (BM-DBM), and parent and modified alpha-, beta- or gamma-cyclodextrins was investigated in water by phase-solubility analysis. Among the available cyclodextrins, only hydroxypropyl-beta-cyclodextrin (HP-beta-CD) produced a significant increase in the aqueous solubility of BM-DBM. The complexation of the sunscreen agent with HP-beta-CD was studied by circular dichroism, differential scanning calorimetry and X-ray diffractometry. The data from the solubility and the circular dichroism studies suggested the formation of a 1:2 (sunscreen:cyclodextrin) complex. The photodegradation of BM-DBM was reduced by inclusion complexation with HP-beta-CD. Therefore the complex can be used to improve the photostability of the sunscreen agent. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：205 / 213

页数：9

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