Development of an in vitro assay for the detection of Botulinum Neurotoxins -: preliminary results

被引：0

作者：

Gessler, F ^{[1
]}

Behrens, S ^{[1
]}

Loch, P ^{[1
]}

Böhnel, H ^{[1
]}

机构：

[1] Univ Gottingen, Bereich Tierhyg, Inst Pflanzenbau & Tierprod Tropen & Subtropen, D-37077 Gottingen, Germany

来源：

ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN | 1998年 / 15卷

关键词：

botulism; Botulinum neurotoxin; in vitro test; neurotoxin detection;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Botulism is a severe, often lethal intoxication, which affects man and animal. It is caused by the neurotoxins (BoNT) of Clostridium botulinum, an anaerobic spore-former At present the toxin types A-G have been identified. The extreme toxicity of these substances still make the animal testing inevitable. No alternative method could reach the sensitivity of the mouse bioassay. Based on the investigations presented a serological test shall be developed, which concentrates the sample and detects the toxin in one step. Preliminary results of an in vitro test detecting BoNT/D are discussed.

引用

页码：62 / 64

页数：3