New Cyanoarylporphyrazines with High Sensitivity of Photophysical Parameters to Viscosity as Promising Agents for Photodynamic Therapy

被引：6

作者：

Lermontova, S. A. ^{[1
]}

Lyubova, T. S. ^{[1
]}

Ladilina, E. Yu. ^{[1
]}

Plekhanov, V. I. ^{[2
]}

Balalaeva, I. V. ^{[3
]}

Boyarskii, V. P. ^{[4
]}

Klapshina, L. G. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Razuvaev Inst Organometall Chem, Nizhnii Novgorod 603950, Russia

[2] Russian Acad Sci, Inst Appl Phys, Nizhnii Novgorod 603950, Russia

[3] Lobachevsky State Univ Nizhny Novgorod, Nizhnii Novgorod 603950, Russia

[4] St Petersburg State Univ, St Petersburg 198504, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 02期

关键词：

cyanoarylporphyrazines; photosensitizers; photoinduced and dark cytotoxicity; fluorescent molecular rotors; optical probes of intracellular viscosity; PHOTOSENSITIZERS; PORPHYRAZINES;

D O I：

10.1134/S1070363220020140

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photophysical properties and photodynamic activity for a series of cyanoarylporphyrazine pigments have been analyzed depending on the nature of the substituents and their position in the aromatic ring. Replacement of the fluorine atom in the para-position with the methoxy group leads to significant increase in the ratio of the dark and photoinduced cytotoxicities, i.e. potential therapeutic index of porphyrazine as photosensitizer in photodynamic cancer therapy.

引用

页码：249 / 256

页数：8

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