NKT cell frequency in Japanese type 1 diabetes

被引：9

作者：

Oikawa, Y ^{[1
]}

Shimada, A ^{[1
]}

Yamada, S ^{[1
]}

Motohashi, Y ^{[1
]}

Nakagawa, Y ^{[1
]}

Irie, J ^{[1
]}

Maruyama, T ^{[1
]}

Saruta, T ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med,Shinjuku Ku, Tokyo 1608582, Japan

来源：

IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN | 2003年 / 1005卷

关键词：

type; 1; diabetes; NKT cell;

D O I：

10.1196/annals.1288.033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in islet-associated Ab+ and Ab- Japanese "classic" type I diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.

引用

页码：230 / 232

页数：3

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