Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall

被引：73

作者：

Figueiredo, Rodrigo Tinoco ^{[2
]}

Bittencourt, Vera Carolina B.

Lopes, Livia Cristina L. ^{[1
]}

Sassaki, Guilherme ^{[3
]}

Barreto-Bergter, Eliana ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Microbiol, Dept Microbiol Geral, BR-21941 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Ciencias Biomed Polo Xerem, BR-21941 Rio De Janeiro, Brazil

[3] Univ Fed Parana, Dept Bioquim & Biol Mol, BR-80060000 Curitiba, Parana, Brazil

来源：

CARBOHYDRATE RESEARCH | 2012年 / 356卷

关键词：

Pseudallescheria boydii; Scedosporium apiospermum; alpha-Glucans; Rhamnomannans; Innate immunity; Toll-like receptors; O-LINKED OLIGOSACCHARIDES; CANDIDA-ALBICANS; SCEDOSPORIUM-APIOSPERMUM; SACCHAROMYCES-CEREVISIAE; PATTERN-RECOGNITION; IMMUNE RECOGNITION; BETA-GLUCANS; DECTIN-1; ALPHA; ACTIVATION;

D O I：

10.1016/j.carres.2012.02.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pseudallescheria boydii is an opportunistic fungus widespread in the environment, and has recently emerged as an agent of localized as well as disseminated infections in both immunocompromised and immunocompetent hosts. The host response to fungi is in part dependent on the activation of evolutionary conserved receptors including Toll-like receptors and phagocytic receptors. This review will discuss the isolation and structural characterization of alpha-glucans and rhamnomannans from P. boydii cell wall and their roles in the induction of innate immune response. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：260 / 264

页数：5

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