Primary position upbeat nystagmus

被引：11

作者：

Adamec, Ivan ^{[1
,2
]}

Gabelic, Tereza ^{[1
,2
]}

Krbot, Magdalena ^{[1
,2
]}

Ozretic, David ^{[3
]}

Milivojevic, Iva ^{[4
]}

Habek, Mario ^{[1
,2
,5
]}

机构：

[1] Zagreb Sch Med, Dept Neurol, HR-10000 Zagreb, Croatia

[2] Referral Ctr Demyelinating Dis Cent Nervous Syst, Univ Hosp Ctr, HR-10000 Zagreb, Croatia

[3] Univ Hosp Ctr Zagreb, Dept Radiol, Zagreb, Croatia

[4] Gen Hosp Zadar, Dept Phys Med & Rehabil, Zadar, Croatia

[5] Univ Zagreb, Sch Med, Zagreb 41001, Croatia

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2012年 / 19卷 / 01期

关键词：

Clinically isolated syndrome; Nucleus intercalates; Primary position upbeat nystagmus; VEMP;

D O I：

10.1016/j.jocn.2011.05.028

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Primary position upbeat nystagmus is a rare clinical finding. We report a patient with clinically isolated syndrome suggestive of multiple sclerosis who presented with primary position upbeat nystagmus. MRI revealed a demyelinating lesion in the lower medulla, which affected the nucleus intercalatus; this type of lesion inhibits the flocculovestibular inhibitory pathway, thereby causing upbeat nystagmus. Nystagmus still persisted after pulsed corticosteroid therapy. This could be due to a loss of central adaptation of the vestibulo-ocular system in our patient, because of more diffuse brainstem damage, shown on vestibular-evoked myogenic potentials as delayed latencies on both sternocleidomastoid muscles and a conduction block for the left extraocular muscles. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：161 / 162

页数：2

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