Organocatalytic enantioselective Michael addition of a kojic acid derivative to nitro olefins

被引：19

作者：

Wang, Jiyu ^{[1
,2
]}

Zhang, Qing ^{[1
]}

Zhang, Hui ^{[1
,2
]}

Feng, Yujun ^{[1
]}

Yuan, Weicheng ^{[1
]}

Zhang, Xiaomei ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 15期

关键词：

FRIEDEL-CRAFTS ALKYLATION; ASYMMETRIC CONJUGATE ADDITION; BETA(2)-AMINO ACIDS; STEREOCONTROLLED CONSTRUCTION; RECYCLABLE ORGANOCATALYST; 3-SUBSTITUTED OXINDOLES; BETA-NITROACRYLATES; TUMOR PROMOTERS; NITROALKENES; NITROOLEFINS;

D O I：

10.1039/c2ob07192d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By employing a chiral bifunctional thiourea-tertiary amine as catalyst, enantioselective Michael addition of a kojic acid derivative to nitro olefins was realised. The reactions afforded the products with good yields (up to 99%) in good enantioselectivities (up to 97% ee). In addition, the absolute configuration of one product was determined.

引用

页码：2950 / 2954

页数：5

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