Electron crystallography of aquaporins

被引：9

作者：

Andrews, Simeon ^{[1
]}

Reichow, Steve L. ^{[1
]}

Gonen, Tamir ^{[1
]}

机构：

[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

IUBMB LIFE | 2008年 / 60卷 / 07期

关键词：

aquaporin; electron crystallography; lipid-protein interactions; membrane junction; channel;

D O I：

10.1002/iub.53

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aquaporins are a family of ubiquitous membrane proteins that form a pore for the permeation of water. Both electron and X-ray crystallography played major roles in determining the atomic structures of a number of aquaporins. This review focuses on electron crystallography, and its contribution to the field of aquaporin biology. We briefly discuss electron crystallography and the two-dimensional crystallization process. We describe features of aquaporins common to both electron and X-ray crystallographic structures; as well as some structural insights unique to electron crystallography, including aquaporin junction formation and lipid-protein interactions. (c) 2008 IUBMB.

引用

页码：430 / 436

页数：7

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