Aplicyanins A-F, new cytotoxic bromoindole derivatives from the marine tunicate Aplidium cyaneum

被引：59
|
作者：
Reyes, Fernando [1 ]
Fernandez, Rogelio [1 ]
Rodriguez, Alberto [1 ]
Francesch, Andres [1 ]
Taboada, Sergi [2 ]
Avila, Conxita [2 ]
Cuevas, Carmen [1 ]
机构：
[1] PharmaMar SAU Pol Ind, R&D Dept, Madrid 28770, Spain
[2] Univ Barcelona, Fac Biol, Dept Anim Biol Invertebrates, E-08028 Barcelona, Spain
来源：
TETRAHEDRON | 2008年 / 64卷 / 22期
关键词：
marine metabolites; bromoindole; cytotoxicity; antimitotic; Antarctic tunicates;
D O I：
10.1016/j.tet.2008.03.060
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Six new bromoindole derivatives, aplicyanins A-F (1-6), have been isolated from the CH2Cl2/MeOH extract of the tunicate Aplidium cyoneum collected in Antarctica. Their structures were determined by extensive analysis of their spectroscopic features, particularly 1D and 2D NMR spectra, and comparison with related compounds Cytotoxic and antimitotic activities were found for compounds 2 and 4 6. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5119 / 5123
页数：5
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