Effects of highly purified sardine proteins on lipid peroxidation and reverse cholesterol transport in rats fed a cholesterol-rich diet

被引:7
|
作者
Louala, Sabrine [1 ]
Hamza-Reguig, Sherazed [1 ]
Benyahia-Mostefaoui, Aicha [1 ]
Boualga, Ahmed [1 ]
Lamri-Senhadji, Myriem Y. [1 ]
机构
[1] Univ Oran, Dept Biol, Fac Sci, LNCM, Oran 31000, Algeria
关键词
Rat; Sardine; LCAT; Lipid peroxidation; Lipoproteins; Cholesterol; DENSITY-LIPOPROTEIN; LIVER CHOLESTEROL; RAPID METHOD; OLIVE OIL; PLASMA; SERUM; COD;
D O I
10.1016/j.jff.2011.07.002
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The effect of highly purified sardine proteins was compared with that of casein on serum and lipoproteins lipid peroxidation and reverse cholesterol transport. Lecithin: cholesterol acyltransferase (LCAT) activity, high density lipoproteins (HDL2 and HDL3) composition and serum lipid and lipoproteins peroxidation were determined in rats fed a cholesterol-rich diet. Hypercholesterolemic rats were divided into two groups fed diets enriched with cholesterol and containing 20% of highly purified sardine proteins (SPc) or casein (CASc) for 28 days. A control group was fed a standard diet (CAS). Compared with CAS and CASc, the thiobarbituric acid reactive substances (TBARS) concentrations of low density lipoprotein (LDL)-HDL1 in SPc were 3.5- and 1.7-fold higher compared with casein diets. TBARS in HDL2 and HDL3 were, respectively, 2.3- and 1.6-fold lower in SPc compared with CASc. In SPc group, LCAT activity was higher compared to CASc and CAS (P <0.05). Purified sardine proteins had no beneficial effects on LDL-cholesterol and lipid peroxidation. However, they reduced HDL oxidation and improved reverse cholesterol transport, in the hypercholesterolemic rat. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:321 / 328
页数:8
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