Role of Diffusion and Perfusion MRI in Selecting Patients for Reperfusion Therapies

被引：8

作者：

Grigoryan, Mikayel ^{[1
]}

Tung, Christie E. ^{[1
]}

Albers, Gregory W. ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Dept Neurol & Neurol Sci, Stanford Stroke Ctr, Palo Alto, CA 94304 USA

来源：

NEUROIMAGING CLINICS OF NORTH AMERICA | 2011年 / 21卷 / 02期

关键词：

MRI; Diffusion; Perfusion; Mismatch; Penumbra; ACUTE ISCHEMIC-STROKE; MIDDLE CEREBRAL-ARTERY; TISSUE-PLASMINOGEN ACTIVATOR; SYMPTOMATIC INTRACEREBRAL HEMORRHAGE; EARLY RECANALIZATION; EVOLUTION DEFUSE; BLOOD-FLOW; PENUMBRA; INFARCTION; THROMBOLYSIS;

D O I：

10.1016/j.nic.2011.01.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

After onset of ischemic stroke, potentially viable tissue at risk (ischemic penumbra) may be salvageable. Currently, intravenous alteplase is approved for up to 4.5 hours after symptom onset of acute ischemic stroke. Increasing this time window may allow many more patients to be treated. The ability to use MRI to help define the irreversibly damaged brain (infarct core) and the reversible ischemic penumbra shows great promise for stroke treatment. Recent advances in penumbral imaging technology may enable a phase III trial of an intravenous thrombolytic to be performed beyond 4.5 hours using techniques to select patients with penumbral tissue.

引用

页码：247 / +

页数：13

共 50 条

[1] Perfusion/Diffusion Mismatch Is Valid and Should Be Used for Selecting Delayed Interventions
Davis, Stephen
Campbell, Bruce
Christensen, Soren
Ma, Henry
Desmond, Patricia
Parsons, Mark
Levi, Christopher
Bladin, Christopher
Barber, P. Alan
Donnan, Geoffrey
TRANSLATIONAL STROKE RESEARCH, 2012, 3 (02) : 188 - 197
[2] Assessment of baseline hemodynamic parameters within infarct progression areas in acute stroke patients using perfusion-weighted MRI
Ritzenthaler, Thomas
Cho, Tae-Hee
Wiart, Marlene
Berthiller, Julien
Ostergaard, Leif
Hermier, Marc
Derex, Laurent
Berthezene, Yves
Nighoghossian, Norbert
NEURORADIOLOGY, 2011, 53 (08) : 571 - 576
[3] Patient selection for thrombolysis using perfusion and diffusion MRI. An overview
Thomalla, G.
Ringleb, P.
Koehrmann, M.
Schellinger, P. D.
NERVENARZT, 2009, 80 (02): : 119 - +
[4] Perfusion-Diffusion Mismatch: Does It Identify Who Will Benefit from Reperfusion Therapy?
Powers, William J.
TRANSLATIONAL STROKE RESEARCH, 2012, 3 (02) : 182 - 187
[5] Oxygen metabolism MRI - A comparison with perfusion imaging in a rat model of MCA branch occlusion and reperfusion
Little, Philip, V
Kraft, Sandra E.
Chireh, Arvin
Damberg, Peter
Holmin, Staffan
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2020, 40 (11) : 2315 - 2327
[6] Intracranial Hemorrhage After Reperfusion Therapies in Acute Ischemic Stroke Patients
Maier, Benjamin
Desilles, Jean Philippe
Mazighi, Mikael
FRONTIERS IN NEUROLOGY, 2020, 11
[7] Search for a Map and Threshold in Perfusion MRI to Accurately Predict Tissue Fate: A Protocol for Assessing Lesion Growth in Patients with Persistent Vessel Occlusion
Galinovic, Ivana
Ostwaldt, Ann-Christin
Soemmer, Carina
Bros, Helena
Hotter, Benjamin
Brunecker, Peter
Schmidt, Wolf U.
Jungehuelsing, Jan
Fiebach, Jochen B.
CEREBROVASCULAR DISEASES, 2011, 32 (02) : 186 - 193
[8] Evaluation of Changes in Cerebral Structures in Migraine Patients with Diffusion and Perfusion MRI
Erdemoglu, Ali Kemal
Ocaklilar, Ebru Kocacikli
Yilmaz, Sevda
TURKISH JOURNAL OF NEUROLOGY, 2013, 19 (02) : 44 - 51
[9] Diffusion-perfusion MRI for triaging transient ischemic attack and acute cerebrovascular syndromes
Olivot, Jean-Marc
Albers, Gregory W.
CURRENT OPINION IN NEUROLOGY, 2011, 24 (01) : 44 - 49
[10] Efficacy of systemic thrombolysis within 4.5 h from stroke symptom onset: a single-centre clinical and diffusion-perfusion 3T MRI study
Floris, Roberto
Cozzolino, Valeria
Meschini, Alessandro
Garaci, Francesco
Konda, Daniel
Marziali, Simone
Sallustio, Fabrizio
Di Legge, Silvia
Claroni, Giulia
Fanucci, Ezio
Simonetti, Giovanni
Stanzione, Paolo
RADIOLOGIA MEDICA, 2014, 119 (10): : 767 - 774

← 1 2 3 4 5 →