Gelatin microcapsules for enhanced microwave tumor hyperthermia

被引：48

作者：

Du, Qijun ^{[1
,2
]}

Fu, Changhui ^{[1
]}

Tie, Jian ^{[3
]}

Liu, Tianlong ^{[1
]}

Li, Linlin ^{[1
]}

Ren, Xiangling ^{[1
]}

Huang, Zhongbing ^{[2
]}

Liu, Huiyu ^{[1
]}

Tang, Fangqiong ^{[1
]}

Li, Li ^{[4
]}

Meng, Xianwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Micro Nanomat & Technol, Lab Controllable Preparat & Applicat Nanomat, Beijing 100190, Peoples R China

[2] Sichuan Univ, Coll Mat Sci & Engn, Chengdu 610065, Peoples R China

[3] Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Radiat Oncol, Beijing 100142, Peoples R China

[4] 452 Hosp Chinese PLA, Dept Oncol, Chengdu 610021, Peoples R China

来源：

NANOSCALE | 2015年 / 7卷 / 07期

基金：

中国国家自然科学基金;

关键词：

INTENSITY FOCUSED ULTRASOUND; GOLD NANOSHELLS; PHOTOTHERMAL THERAPY; SILICA NANORATTLES; ABLATION; GRAPHENE; BIODISTRIBUTION; RADIOFREQUENCY; NANOTECHNOLOGY; NANOPARTICLES;

D O I：

10.1039/c4nr07104b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Local and rapid heating by microwave (MW) irradiation is important in the clinical treatment of tumors using hyperthermia. We report here a new thermo-seed technique for the highly efficient MW irradiation ablation of tumors in vivo based on gelatin microcapsules. We achieved 100% tumor elimination in a mouse model at an ultralow power of 1.8 W without any side-effects. The results of MTT assays, a hemolysis test and the histological staining of organs indicated that the gelatin microcapsules showed excellent compatibility with the physiological environment. A possible mechanism is proposed for MW hyperthermia using gelatin microcapsules. We also used gelatin microcapsules capped with CdTe quantum dots for in vivo optical imaging. Our study suggests that these microcapsules may have potential applications in imaging-guided cancer treatment.

引用

页码：3147 / 3154

页数：8

共 53 条

[1]

Ahmed O, 2013, J CONTROL RELEASE, V172, P1075

[2] Clinical and future applications of high intensity focused ultrasound in cancer [J].

Al-Bataineh, Osama ;

Jenne, Juergen ;

Huber, Peter .

CANCER TREATMENT REVIEWS, 2012, 38 (05) :346-353

[3] Nanoparticle and targeted systems for cancer therapy [J].

Brannon-Peppas, L ;

Blanchette, JO .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (11) :1649-1659

[4]

Carrafiello Gianpaolo, 2008, Int J Surg, V6 Suppl 1, pS65, DOI 10.1016/j.ijsu.2008.12.028

[5] Microwave absorption enhancement and complex permittivity and permeability of Fe encapsulated within carbon nanotubes [J].

Che, RC ;

Peng, LM ;

Duan, XF ;

Chen, Q ;

Liang, XL .

ADVANCED MATERIALS, 2004, 16 (05) :401-+

[6] Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High-Intensity Focused Ultrasound Cancer Surgery [J].

Chen, Yu ;

Chen, Hangrong ;

Sun, Yang ;

Zheng, Yuanyi ;

Zeng, Deping ;

Li, Faqi ;

Zhang, Shengjian ;

Wang, Xia ;

Zhang, Kun ;

Ma, Ming ;

He, Qianjun ;

Zhang, Linlin ;

Shi, Jianlin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (52) :12505-12509

[7] Thermal ablation of tumours: biological mechanisms and advances in therapy [J].

Chu, Katrina F. ;

Dupuy, Damian E. .

NATURE REVIEWS CANCER, 2014, 14 (03) :199-208

[8] Emerging implications of nanotechnology on cancer diagnostics and therapeutics [J].

Cuenca, Alex G. ;

Jiang, Huabei ;

Hochwald, Steven N. ;

Delano, Matthew ;

Cance, William G. ;

Grobmyer, Stephen R. .

CANCER, 2006, 107 (03) :459-466

[9] Sequential pathological and immunologic analysis of percutaneous microwave coagulation therapy of hepatocellular carcinoma [J].

Dong, BW ;

Zhang, J ;

Liang, P ;

Yu, XL ;

Su, L ;

Yu, DJ ;

Ji, XL ;

Yu, G .

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2003, 19 (02) :119-133

[10]

Ester V., 2009, ACS NANO, V3, P3819

← 1 2 3 4 5 6 →