The brain and cytokines - the mutual origin of depression, obesity and cardiovascular diseases?

被引:8
作者
Ufnal, Marcin [1 ]
Wolynczyk-Gmaj, Dorota [2 ]
机构
[1] Warszawski Uniwersytet Med, Katedra & Zaklad Fizjol Doswiadczalnej & Klin, Warsaw, Poland
[2] Warszawski Uniwersytet Med, Katedra & Klin Psychiat, Warsaw, Poland
来源
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2011年 / 65卷
关键词
cytokines; brain; inflammation; cardiovascular diseases; depression; obesity; hypertension; myocardial infarction; heart failure; TUMOR-NECROSIS-FACTOR; CENTRAL-NERVOUS-SYSTEM; CENTRALLY ADMINISTERED INTERLEUKIN-1-BETA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CILIARY NEUROTROPHIC FACTOR; CENTRAL PRESSOR ACTION; FACTOR-ALPHA; TNF-ALPHA; ANGIOTENSIN-II; BLOOD-PRESSURE;
D O I
10.5604/17322693.939284
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Accumulating evidence points to a pivotal role of the brain in the regulation of the circulatory system and energy balance. It has also been found that common civilization diseases such as depression, obesity, hypertension, myocardial infarction or heart failure are accompanied by an increase in concentration of inflammatory mediators in the blood, cerebrospinal fluid and various tissues. Recent studies have revealed that inflammatory mediators that are synthesized peripherally or in the brain may affect the nervous regulation of animal body systems. For example, it has been found that non-specific pro-inflammatory stimuli as well as treatment with several cytokines may cause depressive behavior, disturbances in energy balance and alterations in the circulatory system. On the other hand, knockout of genes for pro-inflammatory cytokines or administration of anti-inflammatory mediators may normalize the pathological changes. In the present manuscript we will review studies that imply the common neuroinflammatory pathogenesis of cardiovascular diseases, depression and energy balance disorders.
引用
收藏
页码:228 / 235
页数:8
相关论文
共 106 条
  • [91] Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: Actions and mechanisms of action
    Turnbull, AV
    Rivier, CL
    [J]. PHYSIOLOGICAL REVIEWS, 1999, 79 (01) : 1 - 71
  • [92] Inhibition of brain nitric oxide synthesis enhances and prolongs the hypertensive effect of centrally administered interleukin-1β in rats
    Ufnal, M
    Dudek, M
    Szczepanska-Sadowska, E
    [J]. CYTOKINE, 2006, 33 (03) : 166 - 170
  • [93] Blockade of angiotensin II AT1 receptors inhibits pressor action of centrally administered interleukin-1β in Sprague Dawley rats
    Ufnal, M
    Zera, T
    Szczepanska-Sadowska, E
    [J]. NEUROPEPTIDES, 2005, 39 (06) : 581 - 585
  • [94] Centrally administered interleukin-1 beta sensitizes to the central pressor action of angiotensin II
    Ufnal, Marcin
    Dudek, Magdalena
    Zera, Tymoteusz
    Szczepanska-Sadowska, Ewa
    [J]. BRAIN RESEARCH, 2006, 1100 : 64 - 72
  • [95] Interleukin-1 receptor antagonist reduces the magnitude of the pressor response to acute stress
    Ufnal, Marcin
    Sikora, Mariusz
    Szczepanska-Sadowska, Ewa
    [J]. NEUROSCIENCE LETTERS, 2008, 448 (01) : 47 - 51
  • [96] Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure
    von Haehling, Stephan
    Doehner, Wolfram
    Anker, Stefan D.
    [J]. CARDIOVASCULAR RESEARCH, 2007, 73 (02) : 298 - 309
  • [97] Intracerebroventricular interleukin-6 treatment decreases body fat in rats
    Wallenius, K
    Wallenius, V
    Sunter, D
    Dickson, SL
    Jansson, JO
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 293 (01) : 560 - 565
  • [98] Central representation of the sympathetic nervous system in the cerebral cortex
    Westerhaus, MJ
    Loewy, AD
    [J]. BRAIN RESEARCH, 2001, 903 (1-2) : 117 - 127
  • [99] Physiological regulation of hypothalamic IL-1β gene expression by leptin and glucocorticoids:: implications for energy homeostasis
    Wisse, BE
    Ogimoto, K
    Morton, GJ
    Wilkinson, CW
    Frayo, RS
    Cummings, DE
    Schwartz, MW
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2004, 287 (06): : E1107 - E1113
  • [100] Interleukin (IL) 1 beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications
    Wong, ML
    Bongiorno, PB
    Rettori, V
    McCann, SM
    Licinio, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (01) : 227 - 232