It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice

被引：26

作者：

Gundry, Michael C. ^{[1
]}

Goodell, Margaret A. ^{[1
,2
,3
,4
]}

Brunetti, Lorenzo ^{[5
]}

机构：

[1] Baylor Coll Med, Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Mol & Human Genet, Houston, TX 77030 USA

[3] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[4] Baylor Coll Med, Stem Cell & Regenerat Med, Houston, TX 77030 USA

[5] Univ Perugia, Dept Med, Perugia, Italy

来源：

CANCER CELL | 2020年 / 37卷 / 03期

关键词：

MODELS;

D O I：

10.1016/j.ccell.2020.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several acute myeloid leukemia genetic sub-types converge on high expression of HOX genes, critical for their self-renewal. A new orally bioavailable Menin-MLL inhibitor (VTP-50469) appears to promote their differentiation through direct effects on the HOX cofactor MEIS1, paving the way for clinical trials.

引用

页码：267 / 269

页数：4

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