The dichotomous nature of T helper 17 cells

被引：330

作者：

Stockinger, Brigitta ^{[1
]}

Omenetti, Sara ^{[1
]}

机构：

[1] Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 09期

关键词：

SEGMENTED FILAMENTOUS BACTERIA; ROR-GAMMA-T; ARYL-HYDROCARBON RECEPTOR; PATHOGENIC T(H)17 CELLS; TH17; CELLS; GUT MICROBIOTA; INTESTINAL INFLAMMATION; REGULATORY NETWORK; INBORN-ERRORS; TGF-BETA;

D O I：

10.1038/nri.2017.50

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper 17 (TH17) cells have been extensively studied since their discovery 10 years ago, primarily because of their known pathogenic role in many inflammatory diseases. Substantial progress has been made in understanding their development, regulation and functional activities, and genome-wide transcriptomic analysis has identified regulatory networks, nodes and interactions that provide vital clues for further studies. In this Review, we describe recent studies that have revealed the dichotomous nature of TH17 cells, which on the one hand allows these cells to be pathogenic drivers of inflammatory disorders and on the other hand allows them to support the integrity of the intestinal barrier in a non-inflammatory manner.

引用

页码：535 / 544

页数：10

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