The Genus Deverra DC. (Syn. Pituranthos Viv.): A natural valuable source of bioactive phytochemicals: A review of traditional uses, phytochemistry and pharmacological properties

The genus Deverra DC. (Apiaceae) comprising only 13 taxa (9 species and 4 subspecies level) with disjunctive distribution in South Africa, in North Africa to Arabian Ecoregion. Thesis, books, Scientific journals, and reports were referred to collect information on the Deverra species. This present work reviewed the literature from 1900 to the end of January 2021. The aim of the review is to highlight traditional uses, phytochemistry and pharmacological properties of the species of the genus. The ethnopharmacologial uses of plant taxa belonging to this genus indicated that plant extracts, Essentail Oils (EOs) and infusion of aerial parts (APs) have been used in traditional popular medicine. The plants are used as a treatment of various purposes, such as asthma, rheumatism, fevers, hepatitis, diabetes and digestive difficulties. This present work focuses on ethnopharmacology of the Deverra species, the phytochemistry, pharmacology, toxicology among other studies on the genus. The present article summarizes on known and potential effects of the Deverra species as well as traditional medicine uses corroborated with pharmacological evidences. By the end of the review, Deverra species have a large application of bioactivities and the most described activities of Deverra plants are attributed to the presence of essential oils, coumarins, furocoumarins, flavonoids and phenolics. Conclusions: The review confirms that some Deverra taxa have been reported as a valuable source for flavoring and as a condiment as well as in the traditional medicine for the treatment of hypertension, to relief stomach pain and against intestinal parasites against spasms, pains, diabetes, hepatitis, digestive difficulties, urinary infections ... etc. Nonetheless, for the valorisation of Deverra species in order to prevent and treat various diseases, further pharmacological investigations are strongly required to determine the mechanism of action, test the safety and the efficacity before starting clinical trials at big scale.