Comparison of the Hypotensive and Bradycardic Activity of Ginkgo, Garlic, and Onion Extracts

被引：26

作者：

Brankovic, Suzana ^{[2
]}

Radenkovic, Mirjana ^{[2
]}

Kitic, Dusanka ^{[1
]}

Veljkovic, Slavimir ^{[2
]}

Ivetic, Vesna ^{[3
]}

Pavlovic, Dragana ^{[1
]}

Miladinovic, Bojana ^{[1
]}

机构：

[1] Univ Nis, Fac Med, Dept Pharm, Nish 18000, Serbia

[2] Univ Nis, Fac Med, Dept Physiol, Nish 18000, Serbia

[3] Univ Novi Sad, Dept Neurophysiol, Fac Med, Novi Sad 21000, Serbia

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2011年 / 33卷 / 02期

关键词：

Ginkgo biloba; Allium sativum; allium cepa; rat; arterial blood pressure; heart rate; BILOBA EXTRACT; ALLIUM-SATIVUM; BLOOD-PRESSURE; METABOLISM; ALLICIN; EGB-761; STRESS; AORTA; RATS; CEPA;

D O I：

10.3109/10641963.2010.531833

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The acute effect of ethanol extracts ginkgo (Ginkgo biloba L.), garlic (Allium sativum L.), and onion (Allium cepa L.) on arterial blood pressure (BP), and heart rate (HR) in anesthetized normotensive rats was examined and compared. Arterial BP was registered in the left carotid artery. The data showed that intravenous administration of the extracts produced dose-dependent and reversible hypotensive and bradycardic effects. The most effective in reducing arterial BP and HR is extract of garlic. There were statistically significant differences in bradycardic and hypotensive effects of the garlic and ginkgo extracts.

引用

页码：95 / 99

页数：5

共 36 条

[1] Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet [J].

Ali, M ;

Al-Qattan, KK ;

Al-Enezi, F ;

Khanafer, RMA ;

Mustafa, T .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2000, 62 (04) :253-259

[2] Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance [J].

Ali, M ;

Thomson, M ;

Afzal, M .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2000, 62 (02) :55-73

[3]

Augusti K. T., 1996, Indian Journal of Experimental Biology, V34, P634

[4]

Ayaz Erol, 2007, Turkiye Parazitoloji Dergisi, V31, P145

[5] Prolongation of life span in hypertensive rats by dietary interventions. Effects of garlic and linseed oil [J].

Brandle, M ;

AlMakdessi, S ;

Weber, RK ;

Dietz, K ;

Jacob, R .

BASIC RESEARCH IN CARDIOLOGY, 1997, 92 (04) :223-232

[6] Protective effect of chronic garlic intake on elastic properties of aorta in the elderly [J].

BreithauptGrogler, K ;

Ling, M ;

Boudoulas, H ;

Belz, GG .

CIRCULATION, 1997, 96 (08) :2649-2654

[7] Aged garlic extract retards progression of coronary artery calcification [J].

Budoff, M .

JOURNAL OF NUTRITION, 2006, 136 (03) :741S-744S

[8]

CHANDORKAR A G, 1973, Indian Journal of Physiology and Pharmacology, V17, P132

[9] Ginkgo biloba extract:: Mechanisms and clinical indications [J].

Diamond, BJ ;

Shiflett, SC ;

Feiwel, N ;

Matheis, RJ ;

Noskin, O ;

Richards, JA ;

Schoenberger, NE .

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2000, 81 (05) :668-678

[10] Antioxidant capacity in Ginkgo biloba [J].

Goh, LM ;

Barlow, PJ .

FOOD RESEARCH INTERNATIONAL, 2002, 35 (09) :815-820

← 1 2 3 4 →