Synthesis of poly(acrylic acid) (PAA) modified Pluronic P123 copolymers for pH-stimulated release of Doxorubicin

被引:34
作者
Choo, Eugene Shi Guang [1 ]
Yu, Bin [1 ]
Xue, Junmin [1 ]
机构
[1] Natl Univ Singapore, Fac Engn, Dept Mat Sci & Engn, Singapore 117574, Singapore
关键词
Atom transfer radical polymerization (ATRP); Doxorubicin; Drug release; pH-responsive; Self-assembly; BLOCK-COPOLYMERS; DRUG-DELIVERY; MOLECULAR-WEIGHT; EXTRACELLULAR PH; TUMOR-ACIDITY; QUANTUM DOTS; CANCER; NANOPARTICLES; COMPLEXATION; MICELLES;
D O I
10.1016/j.jcis.2011.03.047
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Pluronic P123 was chain-extended at their terminal groups using atom transfer radical polymerization to form poly(acrylic acid) (PAA) tails and obtain the PAA-b-P123-b-PAA (P123-PAA) copolymer. The incorporation of PAA had the effect of increasing the carrier's drug loading capacity of an anti-cancer drug, Doxorubicin (DOX), and also allowed for pH-controlled release of the drug. Drug release assays showed that up to 60% of DOX cargo could be retained in the DOX/P123-PAA complex for 3 days at normal physiological pH (7.4). This was then followed by a secondary burst release of DOX when the environment became more acidic (pH 5). Therefore, it was possible that the more acidic physiological environment of tumor sites could be used to trigger an accelerated release of DOX from the drug carriers. The material was demonstrated for potential application in the delivery of cationic drugs for cancer treatment. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:462 / 470
页数:9
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