Synthesis of 5-(6-Pyridazinone-3-yl)-2-glycosylamino-1,3,4-thiadiazoles

被引：3
|
作者：
Tao, Jing [1 ]
Wang, Duo-Zhi [1 ]
Cao, Ling-Hua [1 ]
机构：
[1] Xinjiang Univ, Dept Chem, Urumqi Xinjiang 830046, Peoples R China
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2010年 / 57卷 / 5A期
基金：
中国国家自然科学基金;
关键词：
Pyridazinone; Thiosemicarbazide; 1,3,4-Thiadiazole; SUBSTITUTED 1,3,4-THIADIAZOLES; ANTICONVULSANT ACTIVITY; HETEROCYCLIC-COMPOUNDS; DERIVATIVES; ACID;
D O I：
10.1002/jccs.201000151
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-Glycosyl-2-(1,4,5,6-tetrahydropyridazin-6-one-3-carbonyl)-hydrazinecarbothioamides (3a-3f) and N-glycosyl-2-(1,6-dihydropyridazin-6-one-3-carbonyl)-hydrazinecarbothioamides (5a-5f) were prepared by the reaction of glycosyl isothiocyanates with the compounds 1,4,5,6-tetrahydro-3-hydrozinecarbonyl-6-pyridazinone (1) and 1,6-dihydro-3-hydrozinecarbonyl-6-pyridazinone (2). The terminal heterocyclic compounds 1,3,4-thiadiazoles derivatives were obtained from cyclization of compounds 3a-3f and 5a-5f by phosphoric acid. The structures of all the compounds were confirmed by elemental analysis and IR, H-1 NMR, LC-MS (ESI) spectral data.
引用
收藏
页码：1077 / 1080
页数：4
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