Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

被引：49
|
作者：
Saeed, S. [1 ]
Logie, C. [1 ]
Stunnenberg, H. G. [1 ]
Martens, J. H. A. [1 ]
机构：
[1] Radboud Univ Nijmegen, Fac Sci, Nijmegen Ctr Mol Life Sci, Dept Mol Biol, NL-6500 HB Nijmegen, Netherlands
来源：
BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 04期
关键词：
PML-RAR alpha; RXR; PU.I (SPII); epigenome; TRANSCRIPTION FACTOR; HISTONE DEACETYLASE; FUSION PROTEINS; RECEPTOR; PU.1; RXR; TRANSLOCATION; RECRUITMENT; DEGRADATION; T(15-17);
D O I：
10.1038/sj.bjc.6606095
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PML-RAR (retinoic acid receptor) a is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RAR alpha target genes, its interplay with RXR and deregulation of epigenetic modifications. British Journal of Cancer (2011) 104, 554-558. doi:10.1038/sj.bjc.6606095 www.bjcancer.com Published online 18 January 2011 (C) 2011 Cancer Research UK
引用
收藏
页码：554 / 558
页数：5
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