The Association of MMP7 Promoter Polymorphisms With Gastric Cancer

被引：11
作者：
Fu, Chun-Kai [1 ,2 ,3 ]
Chien, Yi-Chun [4 ]
Chuang, Hui-Yen [5 ]
Wang, Yun-Chi [3 ]
Hwang, Jeng-Jong [5 ,6 ]
Yang, Mei-Due [3 ]
Yu, Chien-Chih [3 ]
Chen, Jaw-Chyun [7 ]
Chang, Wen-Shin [3 ]
Bau, Da-Tian [1 ,3 ,8 ]
Tsai, Chia-Wen [3 ]
机构：
[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan
[2] Taichung Armed Forces Gen Hosp, Taichung, Taiwan
[3] China Med Univ Hosp, Translat Med Ctr, Terry Fox Canc Res Lab, Taichung, Taiwan
[4] I Shou Univ, Dept Med Imaging & Radiol Sci, Kaohsiung, Taiwan
[5] Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
[6] Chung Shan Med Univ Hosp, Dept Med Imaging, Taichung, Taiwan
[7] Da Yeh Univ, Dept Med Bot & Hlth Applicat, Changhua, Taiwan
[8] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan
来源：
ANTICANCER RESEARCH | 2020年 / 40卷 / 02期
关键词：
Gastric cancer; genotype; MMP7; polymorphism; Taiwan; MATRIX METALLOPROTEINASE-7; GENE POLYMORPHISMS; COLORECTAL-CANCER; STOMACH-CANCER; RISK-FACTORS; LUNG-CANCER; GENOTYPES; SUSCEPTIBILITY; ADENOCARCINOMA; PROGRESSION;
D O I：
10.21873/anticanres.13999
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time. Materials and Methods: A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum. Results: The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population. Conclusion: The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed.
引用
收藏
页码：695 / 702
页数：8
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