The Association of MMP7 Promoter Polymorphisms With Gastric Cancer

被引：11

作者：

Fu, Chun-Kai ^{[1
,2
,3
]}

Chien, Yi-Chun ^{[4
]}

Chuang, Hui-Yen ^{[5
]}

Wang, Yun-Chi ^{[3
]}

Hwang, Jeng-Jong ^{[5
,6
]}

Yang, Mei-Due ^{[3
]}

Yu, Chien-Chih ^{[3
]}

Chen, Jaw-Chyun ^{[7
]}

Chang, Wen-Shin ^{[3
]}

Bau, Da-Tian ^{[1
,3
,8
]}

Tsai, Chia-Wen ^{[3
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] Taichung Armed Forces Gen Hosp, Taichung, Taiwan

[3] China Med Univ Hosp, Translat Med Ctr, Terry Fox Canc Res Lab, Taichung, Taiwan

[4] I Shou Univ, Dept Med Imaging & Radiol Sci, Kaohsiung, Taiwan

[5] Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan

[6] Chung Shan Med Univ Hosp, Dept Med Imaging, Taichung, Taiwan

[7] Da Yeh Univ, Dept Med Bot & Hlth Applicat, Changhua, Taiwan

[8] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 02期

关键词：

Gastric cancer; genotype; MMP7; polymorphism; Taiwan; MATRIX METALLOPROTEINASE-7; GENE POLYMORPHISMS; COLORECTAL-CANCER; STOMACH-CANCER; RISK-FACTORS; LUNG-CANCER; GENOTYPES; SUSCEPTIBILITY; ADENOCARCINOMA; PROGRESSION;

D O I：

10.21873/anticanres.13999

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time. Materials and Methods: A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum. Results: The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population. Conclusion: The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed.

引用

页码：695 / 702

页数：8

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