Protective effects of maternal methyl donor supplementation on adult offspring of high fat diet-fed dams

被引：26

作者：

Jiao, Fei ^{[1
]}

Yan, Xiaoshuang ^{[2
]}

Yu, Yuan ^{[1
]}

Zhu, Xiao ^{[3
]}

Ma, Ying ^{[1
]}

Yue, Zhen ^{[1
]}

Ou, Hailong ^{[4
]}

Yan, Zhonghai ^{[1
,5
]}

机构：

[1] Binzhou Med Coll, Dept Biochem & Mol Biol, Yantai 264003, Shandong, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China

[3] Guangdong Med Univ, Dongguan Sci Res Ctr, Key Lab Med Mol Diagnost, Dongguan 523808, Guangdong, Peoples R China

[4] Guizhou Med Univ, Dept Biochem & Mol Biol, Guiyang 550004, Guizhou Provinc, Peoples R China

[5] Columbia Univ, Dept Med, Coll Phys & Surg, New York, NY 10027 USA

来源：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY | 2016年 / 34卷

关键词：

Obesity; High-fat diet; Methyl supplementation; Epigenetic; DNA methylation; Adipokine; DNA METHYLATION; ADIPOSE-TISSUE; INSULIN-RESISTANCE; OBESITY; NUTRITION; EPIGENETICS; DISEASE; GENE; MECHANISMS; EXPRESSION;

D O I：

10.1016/j.jnutbio.2016.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity has become a global public health problem associated with metabolic dysfunction and chronic disorders. It has been shown that the risk of obesity and the DNA methylation profiles of the offspring can be affected by maternal nutrition, such as high-fat diet (HFD) consumption. The aim of this study was to investigate whether metabolic dysregulation and physiological abnormalities in offspring caused by maternal HFD can be alleviated by the treatment of methyl donors during pregnancy and lactation of dams. Female C57BL/6 mice were assigned to specific groups and given different nutrients (control diet, Control + Met, HFD and HFD + Met) throughout gestation and lactation. Offspring of each group were weaned onto a control diet at 3 weeks of age. Physiological (weight gain and adipose composition) and metabolic (plasma biochemical analyses) outcomes were assessed in male and female adult offspring. Expression and DNA methylation profiles of obesogenic-related genes including PPAR gamma, fatty add synthase, leptin and adiponectin were also detected in visceral fat of offspring. The results showed that dietary supplementation with methyl donors can prevent the adverse effects of maternal HFD on offspring. Changes in the expression and DNA methylation of obesogenic-related genes indicated that epigenetic regulation may contribute to the effects of maternal dietary factors on offspring outcomes. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：42 / 51

页数：10

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