Ultra-wideband Characterization, Electroporation, and Dielectrophoresis of a Live Biological Cell Using the Same Vector Network Analyzer

被引：0

作者：

Du, Xiaotian ^{[1
]}

Ma, Xiao ^{[1
]}

Li, Lei ^{[1
]}

Li, Hang ^{[1
]}

Cheng, Xuanhong ^{[1
]}

Hwang, James C. M. ^{[1
]}

机构：

[1] Lehigh Univ, Bethlehem, PA 18015 USA

来源：

2018 IEEE/MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM - IMS | 2018年

关键词：

Biological cells; biosensors; cellular biophysics; dielectrophoresis; microwave measurements; ultra wideband technology;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

For the first time, single-cell trapping, characterization, electroporation, and de-trapping were demonstrated by conveniently programming the frequency and power of the same ultra-wideband vector network analyzer (VNA). For example, trapping and de-trapping of a cell were accomplished by applying to a coplanar waveguide (CPW) a CW signal of 3 dBm and 5 MHz and 10 kHz, respectively, corresponding to attractive and repulsive dielectrophoresis. After a cell is trapped on the CPW, the VNA was switched to 9 dBm and 100 kHz for electroporation. Before and after electroporation, the cell was characterized from 9 kHz to 9 GHz by setting the VNA at -18 dBm to assess the effect of electroporation. This breakthrough can improve not only the accuracy, but also the throughput of single-cell wideband electrical characterization.

引用

页码：1148 / 1151

页数：4

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